A Multimodal Theranostic Nanoformulation That Dramatically Enhances Docetaxel Efficacy Against Castration Resistant Prostate Cancer

Bulmahn, Julia C.; Kutscher, Hilliard L.; Cwiklinski, Katherine; Schwartz, Stanley A.; Prasad, Paras N.; Aalinkeel, Ravikumar

doi:10.1016/j.xphs.2020.06.004

Cited by 10 publications

(8 citation statements)

References 22 publications

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“…Satisfactory tissue penetration could be achieved using near-infrared (NIR) light, and therefore much attention was focused on upconversion nanoparticles that allow the conversion of NIR to visible light, which is most effective in stimulating the photosensitizer to produce reactive oxygen species (ROS). The zinc (II)-phthalocyanine photosensitizer attached to polyethyleneimine-modified sodium yttrium fluoride (NaYF 4 ) upconversion nanoparticles proved to be unstable [67].…”

Section: Ucnps In Prostate Cancer Treatmentmentioning

confidence: 99%

Section: Ucnps In Prostate Cancer Treatmentmentioning

confidence: 99%

“…Bulmahn et al [67] concentrated on the problem related to the treatment of advanced or recurrent prostate cancer. In such cases, androgen deprivation therapy (ADT) is usually used first, followed by chemotherapy, if necessary [67]. They introduced a multifunctional hierarchical nanoformulation composed of biodegradable chitosan (CS) coated poly (lacticco-glycolic acid) (PLGA) nanocarriers loaded with docetaxel (Doc) and interleukin-8 (IL-8) small interfering RNA (siRNA) electrostatically bound to UCNPs that has been developed for the bioimaging and treatment of castration-resistant (recurrent ADT-resistant) prostate cancer (CRPC).…”

Section: Ucnps In Prostate Cancer Treatmentmentioning

confidence: 99%

“…Next, Poly-D-Lysine coating was performed to produce a positively charged surface to allow for the electrostatic attachment of IL-8 siRNA. The final result was nanocarriers containing UCNPs, siRNA, DTX or a combination of mentioned particles [67].…”

Section: Ucnps In Prostate Cancer Treatmentmentioning

confidence: 99%

“…The encapsulation of UCNP-PDL and the addition of siRNA to the nanoformulation resulted in a~14,000-fold decrease in this value overall. This nanoformulation combined improved drug delivery with providing bimodal fluorescence imaging and MR contrast enhancement [67].…”

Section: Ucnps In Prostate Cancer Treatmentmentioning

confidence: 99%

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The Use of Upconversion Nanoparticles in Prostate Cancer Photodynamic Therapy

Osuchowski

Latos

et al. 2021

Life

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Photodynamic Therapy (PDT) is a cancer treatment that uses light, a photosensitizer, and oxygen to destroy tumors. This article is a review of approaches to the treatment of prostate cancer applying upconversion nanoparticles (UCNPs). UCNPs have become a phenomenon that are rapidly gaining recognition in medicine. They have proven to be highly selective and specific and present a powerful tool in the diagnosis and treatment of prostate cancer. Prostate cancer is a huge health problem in Western countries. Its early detection can significantly improve patients’ prognosis, but currently used diagnostic methods leave much to be desired. Recently developed methodologies regarding UCNP research between the years 2021 and 2014 for prostate cancer PDT will also be discussed. Current limitations in PDT include tissue irradiation with visible wavelengths that have a short tissue penetration depth. PDT with the objectives to synthesize UCNPs composed of a lanthanide core with a coating of adsorbed dye that will generate fluorescence after excitation with near-infrared light to illuminate deep tissue is a subject of intense research in prostate cancer.

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Section: Ucnps In Prostate Cancer Treatmentmentioning

confidence: 99%

Section: Ucnps In Prostate Cancer Treatmentmentioning

confidence: 99%