A multimodal study of impulsivity and body weight: Integrating behavioral, cognitive, and neuroimaging approaches

Filbey, Francesca M.; Yezhuvath, Uma

doi:10.1002/oby.21713

Cited by 19 publications

(11 citation statements)

References 41 publications

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“…27,33 Additionally, regional assessment of the DMN showed an increase in the inferior parietal cortex and posterior cingulate cortex, which integrates food images with visual attention 84 and generates a bias towards food cues, respectively. 85 The post-hoc connectivity analysis corroborates the previous find- were chosen based on previous published work: socio-economic, 86 physiological, 25,69,77,87 cognitive [88][89][90] and heritability. 91,92 Despite these previous relationships, we did not find any association between socio-economic, physiological or cognitive measures and the interaction of age at onset of puberty and adult BMI.…”

Section: Discussionsupporting

confidence: 79%

Earlier onset of menstruation is related to increased body mass index in adulthood and altered functional correlations between visual, task control and somatosensory brain networks

Shearrer

Sadler

Papantoni

et al. 2020

J Neuroendocrinology

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Onset of puberty has been associated with lower body mass index (BMI) in adulthood independent of childhood BMI. However, how the relationship between time of onset of puberty and BMI in adulthood is associated with neurocognitive outcomes is largely unstudied. Here, women were sampled from the Human Connectome Project 1200 PTN release. Inclusion criteria were: 4 (15 minute) resting state fMRI scans, current measured BMI, self-reported age at onset of menstruation (a proxy of age at onset of puberty), and no endocrine complications (e.g., polycystic ovarian syndrome). The effect of age at onset of menstruation, measured BMI at scan date, and the interaction of age at onset of menstruation by BMI on brain functional correlation was modeled using FSLnets controlling for race and age at scan. Corrected significance was set at pFWE<0.05. A final sample of n=510 (age 29.5y±3.6; BMI at scan 25.9±5.6; age at onset of menstruation 12.7±1.6) were included. Age at onset of menstruation was negatively associated with BMI at scan (r=-0.19, p<0.001). The interaction between age at onset of menstruation and BMI at scan was associated with stronger correlation between a somatosensory and visual network (t= 3.45, pFWE= 0.026), and a visual network and cinguloopercular task control network (t= 4.74, pFWE= 0.0002). We show increased correlation between visual, taste-associated, and self-control brain regions in women at high BMI with later age at onset of menstruation. Together, this implies that the association between later menarche and lower BMI may impart improved self-control during exposure to visual cues.

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Section: Discussionsupporting

confidence: 79%

Earlier onset of menstruation is related to increased body mass index in adulthood and altered functional correlations between visual, task control and somatosensory brain networks

Shearrer

Sadler

Papantoni

et al. 2020

J Neuroendocrinology

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“…Common themes were deficits in attention, memory and executive function, the mental processes that underlie higher-order cognition such as deliberation and decision making. Reduced capacity in these domains may lead to a reduction in overall self-regulatory control needed to maintain a healthy lifestyle, giving rise to overeating in ways that are parallel to overconsumption of addictive drugs (Volkow et al., 2012; Filbey and Yezhuvath, 2016). A growing body of literature suggests that neurocognitive impairment and dysregulated self-control seen in obesity may mirror that seen in addictive disorders (Amlung et al., 2016a).…”

Section: Discussionmentioning

confidence: 99%

Deficits in executive function and suppression of default mode network in obesity

Syan

Goodman

Epstein

et al. 2019

NeuroImage: Clinical

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HighlightsUsing a case-control design, obese individuals exhibited worse performance across a number of neurocognitive tests compared to healthy BMI controls, particularly in tasks measuring executive function.In a functional MRI N-Back task measuring working memory performance, obese individuals exhibited greater BOLD activity in task-negative brain regions, suggesting deficits in suppression of the default mode network (DMN).Obese individuals exhibited differences in cortical morphometry in frontal, temporal, and parietal regions linked to executive function.Integrative analyses implicated aspects of behavioral performance, inefficient DMN suppression, and cortical morphometry.Results suggest that obesity is associated with a diverse range of functional, structural and behavioural deficits in executive functioning; longitudinal studies are needed to clarify causal versus consequential influences.

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“…In addition, the following criteria were used to select hazardous drinkers: having an Alcohol Use Disorders Identification Test (AUDIT) total score > 8 ( 36 ) and Fagerstrom Test for Nicotine Dependence (FTND) < 6 (no nicotine dependence). The healthy controls were recruited from two studies: (a) an extension of the genetics of drinking study ( 33 – 35 ); and (b) control comparison of an obesity study ( 37 ), both approved by University of New Mexico Human Research Review Committee and all the participants provided written informed consent. The recruiting criteria for healthy controls included: free of nicotine dependence (self-defined, about half participants provided FTND scores to confirm); free of any alcohol use problems and any problem drinking history (occasional alcohol use was allowed, ADUIT scores were available for participants to confirm); free of any chronic disease, any brain injury, and any substance use other than alcohol.…”

Section: Methodsmentioning

confidence: 99%

Opposite Epigenetic Associations With Alcohol Use and Exercise Intervention

et al. 2018

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Alcohol use disorder (AUD) is a devastating public health problem in which both genetic and environmental factors play a role. Growing evidence supports that epigenetic regulation is one major mechanism in neuroadaptation that contributes to development of AUD. Meanwhile, epigenetic patterns can be modified by various stimuli including exercise. Thus, it is an intriguing question whether exercise can lead to methylation changes that are opposite to those related to drinking. We herein conducted a comparative study to explore this issue. Three cohorts were profiled for DNA methylation (DNAm), including a longitudinal exercise intervention cohort (53 healthy participants profiled at baseline and after a 12-months exercise intervention), a cross-sectional case-control cohort (81 hazardous drinkers and 81 healthy controls matched in age and sex), and a cross-sectional binge drinking cohort (281 drinkers). We identified 906 methylation sites showing significant DNAm differences between drinkers and controls in the case-control cohort, as well as, associations with drinking behavior in the drinking cohort. In parallel, 341 sites were identified for significant DNAm alterations between baseline and follow-up in the exercise cohort. Thirty-two sites overlapped between these two set of findings, of which 15 sites showed opposite directions of DNAm associations between exercise and drinking. Annotated genes of these 15 sites were enriched in signaling pathways related to synaptic plasticity. In addition, the identified methylation sites significantly associated with impaired control over drinking, suggesting relevance to neural function. Collectively, the current findings provide preliminary evidence that exercise has the potential to partially reverse DNAm differences associated with drinking at some CpG sites, motivating rigorously designed longitudinal studies to better characterize epigenetic effects with respect to prevention and intervention of AUD.

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A multimodal study of impulsivity and body weight: Integrating behavioral, cognitive, and neuroimaging approaches

Cited by 19 publications

References 41 publications

Earlier onset of menstruation is related to increased body mass index in adulthood and altered functional correlations between visual, task control and somatosensory brain networks

Earlier onset of menstruation is related to increased body mass index in adulthood and altered functional correlations between visual, task control and somatosensory brain networks

Deficits in executive function and suppression of default mode network in obesity

Opposite Epigenetic Associations With Alcohol Use and Exercise Intervention

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