A multilocus genetic risk score is associated with arterial stiffness in hypertensive patients

Polonis, Katarzyna; Hoffmann, Michal; Szyndler, Anna; Wolf, Jacek; Nowak, Robert; Becari, Christiane; Laurent, Stéphane; Boutouyrie, Pierre; Melander, Olle

doi:10.1097/hjh.0000000000001773

Cited by 5 publications

(2 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The improvement in the ability of each serum lipid to predict outcomes was summarized using area under the receiver operating characteristic (ROC) curves (AUC), positive net reclassification improvement (NRI), and integrated discrimination improvement (IDI) [19]. In sensitivity analyses, TC, TG, HDL-C, LDL-C, and non-HDL were divided into three or two levels by clinical cut-points [20]; TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, and non-HDL-C/HDL-C ratios were divided into three levels by tertile cut-points. ORs and 95% CIs for the outcomes across categories of each serum lipid were also calculated, using the most favorable category as the reference.…”

Section: Discussionmentioning

confidence: 99%

Use of lipid parameters to identify apparently healthy men at high risk of arterial stiffness progression

Sang

Cao

et al. 2021

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background Dyslipidemia contributes to the development and progression of arterial stiffness. We aimed to identify the most informative measures of serum lipids and their calculated ratios in terms of arterial stiffness progression risk. Methods Total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and brachial-ankle pulse wave velocity (baPWV) of 659 healthy males (47.4 ± 10.7 years) were measured at baseline. Values for non-HDL-C, TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, and non-HDL-C/HDL-C were calculated. BaPWV was re-performed after 4.1 years follow-up. Elevated baPWV was defined as baPWV ≥ 1400 cm/s. Results Over the follow-up period, the mean baPWV value increased from 1340 cm/s to 1410 cm/s, and 331 individuals increased/persisted with high baPWV (outcome 1). Among the 448 subjects who had normal baseline baPWV, 100 incident elevated baPWV occurred (outcome 2). Only baseline logTG (OR 1.64 [95% CI: 1.14–2.37] for outcome 1; 1.89 [1.14–3.17] for outcome 2) and logTG/HDL-C (1.54 [1.15–2.10] for outcome 1; 1.60 [1.05–2.45] for outcome 2) were significantly associated with arterial stiffness progression after adjusting for confounding factors. Adding logTG or logTG/HDL-C to age and blood pressure improved the accuracy of risk predictions for arterial stiffness progression. These associations remained significant when lipids were analyzed as categorical variables. Conclusions Baseline serum TG and TG/HDL-C were independently associated with increases in/persistently high baPWV and incident elevated baPWV, and they performed more effectively than other lipid variables in identifying healthy men at high risk of arterial stiffness progression.

show abstract

Section: Discussionmentioning

confidence: 99%

Use of lipid parameters to identify apparently healthy men at high risk of arterial stiffness progression

Sang

Cao

et al. 2021

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

“…The improvement in the ability of each serum lipid to predict outcomes was summarized using area under receiver operating characteristic (ROC) curves (AUC), positive net reclassi cation improvement (NRI), and integrated discrimination improvement (IDI) [15]. In sensitivity analyses, TC, TG, HDL-C, LDL-C, and non-HDL were divided into three or two levels by clinical cut-points [16]; TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, and non-HDL-C/HDL-C ratios were divided into three levels by tertile cut-points.…”

Section: Discussionmentioning

confidence: 99%

Use of Lipid Parameters to Identify Healthy Men at a Higher Risk of Arterial Stiffness Progression

Sang¹,

Cao²,

Wu³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Dyslipidemia contributes to the development and progression of arterial stiffness. We aimed to confirm the superiority of the serum lipids and their calculated ratios in predicting arterial stiffness progression.Methods: Total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and brachial-ankle pulse wave velocity (baPWV) of 612 healthy males (47.0 ± 10.5 years) were measured at baseline. Values for non-HDL-C, TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, and non-HDL-C/HDL-C were calculated. BaPWV was re-performed after 4.1 years follow-up. A baPWV cutoff of 1400 cm/s was used to diagnose arterial stiffness.Results: Over the follow-up period, the mean baPWV value increased from 1330 cm/s to 1400 cm/s, and 309 individuals increased/persisted with high baPWV (outcome 1). Among the 430 subjects who were free of arterial stiffness at baseline, 90 arterial stiffness events occurred (outcome 2). Only logTG (OR 1.65 [95% CI: 1.14-2.40] for outcome 1; 2.08 [1.24-3.52] for outcome 2) and logTG/HDL-C (1.56 [1.15-2.13] for outcome 1; 1.69 [1.10-2.62] for outcome 2) were significantly associated with arterial stiffness progression after adjusting for confounding factors. Adding logTG or logTG/HDL-C to age and blood pressure improved the accuracy of risk predictions for arterial stiffness progression. These associations remained significant when lipids were analyzed as categorical variables.Conclusions: Baseline serum TG and TG/HDL-C were independently associated with increases in/persistently high baPWV and incident arterial stiffness, and they performed more effectively than other lipid variables in identifying healthy men at a higher risk of arterial stiffness progression.

show abstract

The Genetics of Blood Pressure Regulation

Lin¹,

Guo²,

Rotter³

2020

Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics

View full text Add to dashboard Cite

A multilocus genetic risk score is associated with arterial stiffness in hypertensive patients

Cited by 5 publications

References 72 publications

Use of lipid parameters to identify apparently healthy men at high risk of arterial stiffness progression

Use of lipid parameters to identify apparently healthy men at high risk of arterial stiffness progression

Use of Lipid Parameters to Identify Healthy Men at a Higher Risk of Arterial Stiffness Progression

The Genetics of Blood Pressure Regulation

Contact Info

Product

Resources

About