The Genetics of Blood Pressure Regulation

Lin, Henry J.; Guo, Xiuqing; Rotter, Jerome I.

doi:10.1016/b978-0-12-812532-8.00006-9

Cited by 1 publication

(1 citation statement)

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“…Estimated heritability of systolic and diastolic blood pressure lies in the ranges of 15–40% and 15–30%, respectively ( Delles and Padmanabhan, 2012 ). More than 900 known genetic loci indicate that sites for blood pressure control involve various organs, including the kidneys and nervous system ( Lin et al, 2020 ). Therefore, extension of the model to take into account personal data of genetic testing can help resolve the questions regarding individual blood pressure regulation.…”

Section: Discussionmentioning

confidence: 99%

Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease

et al. 2021

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Here we present a modular agent-based mathematical model of the human cardiovascular and renal systems. It integrates the previous models primarily developed by A. C. Guyton, F. Karaaslan, K. M. Hallow, and Y. V. Solodyannikov. We performed the model calibration to find an equilibrium state within the normal vital sign ranges for a healthy adult. We verified the model’s abilities to reproduce equilibrium states with abnormal physiological values related to different combinations of cardiovascular diseases (such as systemic hypertension, chronic heart failure, pulmonary hypertension, etc.). For the model creation and validation, we involved over 200 scientific studies covering known models of the human cardiovascular and renal functions, biosimulation platforms, and clinical measurements of physiological quantities in normal and pathological conditions. We compiled detailed documentation describing all equations, parameters and variables of the model with justification of all formulas and values. The model is implemented in BioUML and available in the web-version of the software.

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Section: Discussionmentioning

confidence: 99%