A multigeneration fish toxicity test as an aid in the hazard evaluation of aquatic pollutants

Newsome, C.S.

doi:10.1016/0147-6513(80)90038-x

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…Ozoh and Jacobson (1979) reported that copper exposure decreased hatching success and increased the number of abnormal larvae. The convict cichlid was chosen by Newsome (1980) as a suitable species to assess toxicity of trisodium carboxymethyloxysuccinate because of its small size, lack of exacting water quality requirements and easy breeding in the laboratory. Recently, Da Cuna et al (2013) reported that Cichlasoma dimerus, a very close species to convict cichlid, exposed to endosulfan evidenced a disruptive effect of this organochlorine pesticide on reproductive axis.…”

Section: Introductionmentioning

confidence: 99%

Reproduction and Behavioral Responses of Convict Cichlid, Amatitlania nigrofasciata to Fluoxetine

Latifi¹,

Forsatkar²,

Nematollah³

2015

J. of Fisheries and Aquatic Science

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Widespread prescription of fluoxetine has led to enter into the aquatic environments which act as an endocrine disruptor for fish. This study examined the effect of fluoxetine on the reproductive consequence of convict cichlid (Amatitlania nigrofasciata), during three successive cycles of spawning. Following pair-bond formation, pairs were divided into four treatments and exposed to concentrations of 0, 0.54, 5.40 or 54.0 μg LG 1 fluoxetine in pre-acclimated spawning tanks. Reproduction was assessed by examination of Egg Number (EN), Incubation Period (IP), Hatching Ratio (HR) and Inter-Spawning Interval (ISI). At the last spawning cycle, behavior and physiochemical properties of fish were determined. Hepatosomatic index (HSI) of males/females was insignificant at the end of the experiment; however, condition factor of males showed a significant difference between 0 and 54.0 μg LG 1 fluoxetine treatments. At 5.40 and 54.0 μg LG 1 of fluoxetine, testosterone were significantly decreased in males. Both main effects of the fluoxetine concentrations and the spawning cycles were significant in the EN, HR and ISI. IP was significantly affected only by fluoxetine. The behaviors, spawning duration and fanning latency were affected in 54.0 μg LG 1 fluoxetine but time spent near the substrate and lipping display were not affected. Results indicated that fluoxetine disrupts reproduction features of convict cichlid. However, significant impacts were mainly observed at higher concentrations than those reported in natural environments (0.54 μg LG 1), so that the impact of fluoxetine on reproductive fitness of cichlid populations might be relatively low.

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Section: Introductionmentioning

confidence: 99%

Reproduction and Behavioral Responses of Convict Cichlid, Amatitlania nigrofasciata to Fluoxetine

Latifi¹,

Forsatkar²,

Nematollah³

2015

J. of Fisheries and Aquatic Science

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“…Despite such compelling evidence that ELS test results are highly predictive of results from longer term exposures including fish reproduction, there have long been calls for greater use of FLC tests [6][7][8]. At a recent Organisation for Economic Cooperation and Development (OECD) workshop to establish a Fish Testing Framework [9], a recommendation was made to scope the need for developing a partial life cycle (PLC) test that would include the reproductive phase.…”

Section: Introductionmentioning

confidence: 99%

An evaluation of fish early life stage tests for predicting reproductive and longer‐term toxicity from plant protection product active substances

Wheeler

Maynard

Crane³

2014

Enviro Toxic and Chemistry

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The chronic toxicity of chemicals to fish is routinely assessed by using fish early life stage (ELS) test results. Fish full life cycle (FLC) tests are generally required only when toxicity, bioaccumulation, and persistence triggers are met or when there is a suspicion of potential endocrine-disrupting properties. This regulatory approach is based on a relationship between the results of fish ELS and FLC studies first established more than 35 yrs ago. Recently, this relationship has been challenged by some regulatory authorities, and it has been recommended that more substances should undergo FLC testing. In addition, a project proposal has been submitted to the Organisation for Economic Cooperation and Development (OECD) to develop a fish partial life cycle (PLC) test including a reproductive assessment. Both FLC and PLC tests are animal- and resource-intensive and technically challenging and should therefore be undertaken only if there is clear evidence that they are necessary for coming to a regulatory decision. The present study reports on an analysis of a database of paired fish ELS and FLC endpoints for plant protection product active substances from European Union draft assessment reports and the US Environmental Protection Agency Office of Pesticide Programs Pesticide Ecotoxicity Database. Analysis of this database shows a clear relationship between ELS and FLC responses, with similar median sensitivity across substances when no-observed-effect concentrations (NOECs) are compared. There was also no indication that classification of a substance as a mammalian reproductive toxicant leads to more sensitive effects in fish FLC tests than in ELS tests. Indeed, the response of the ELS tests was generally more sensitive than the most sensitive reproduction NOEC from a FLC test. This analysis indicates that current testing strategies and guidelines are fit for purpose and that there is no need for fish full or partial life cycle tests for most plant protection product active substances.

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The growth response in fish chronic and early life stage toxicity tests: A critical review

Woltering¹

1984

Aquatic Toxicology

167

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A multigeneration fish toxicity test as an aid in the hazard evaluation of aquatic pollutants

Cited by 4 publications

References 13 publications

Reproduction and Behavioral Responses of Convict Cichlid, Amatitlania nigrofasciata to Fluoxetine

Reproduction and Behavioral Responses of Convict Cichlid, Amatitlania nigrofasciata to Fluoxetine

An evaluation of fish early life stage tests for predicting reproductive and longer‐term toxicity from plant protection product active substances

The growth response in fish chronic and early life stage toxicity tests: A critical review

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