A multifunctional theranostics nanosystem featuring self-assembly of alcohol-abuse drug and photosensitizers for synergistic cancer therapy

Wu, Pengyu; Shen, Zhichun; Zhang, Wenzhong; Jiang, Jiali; Zhang, Bingchen; Lin, Juanfang; Zou, Junjie; Li, Chao; Shao, Jingwei

doi:10.1039/d2bm00803c

Cited by 6 publications

(4 citation statements)

References 52 publications

(57 reference statements)

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“…According to the report, different EDCI/NHS and buffer systems were considered [35][36][37][38][39]. It was found that when the ratio of NHS to EDCI exceeded one, there was almost no unreacted adenine and thymine.…”

Section: Preparation Of Cmc-at Nanofiber Hydrogel Adhesivementioning

confidence: 99%

A Novel Nanofiber Hydrogel Adhesive Based on Carboxymethyl Cellulose Modified by Adenine and Thymine

Xie,

Yang,

Wan

et al. 2024

Polymers

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Natural polymer-based adhesive hydrogels have garnered significant interest for their outstanding strength and versatile applications, in addition to being eco-friendly. However, the adhesive capabilities of purely natural products are suboptimal, which hampers their practical use. To address this, we engineered carboxymethyl cellulose (CMC) surfaces with complementary bases, adenine (A) and thymine (T), to facilitate the self-assembly of adhesive hydrogels (CMC-AT) with a nanofiber configuration. Impressively, the shear adhesive strength reached up to 6.49 MPa with a mere 2% adhesive concentration. Building upon this innovation, we conducted a comparative analysis of the shear adhesion properties between CMC and CMC-AT hydrogel adhesives when applied to delignified and non-delignified wood chips. We examined the interplay between the adhesives and the substrate, as well as the role of mechanical interlocking in overall adhesion performance. Our findings offer a fresh perspective on the development of new biodegradable polymer hydrogel adhesives.

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Section: Preparation Of Cmc-at Nanofiber Hydrogel Adhesivementioning

confidence: 99%

A Novel Nanofiber Hydrogel Adhesive Based on Carboxymethyl Cellulose Modified by Adenine and Thymine

Xie,

Yang,

Wan

et al. 2024

Polymers

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“…Santhamoorthy et al prepared a double-pH and thermosensitive copolymer hydrogel (HG) system (PNIPAm-co-PAAm HG) using N-isopropylacrylamide (NIPAm) and acrylamide (AAm) as comonomers [77]. Wu et al developed a dual-targeted nanoscale drug delivery system based on EpCAM aptamers and lactic acid-modified oligoamide amine dendrimers for the simultaneous delivery of the FDA-approved drug disulfiram and the photosensitizer indocyanine green, thereby realizing a system that combined imaging and therapeutic functions in a single platform [78]. Wu et al also prepared a dual-gated folate functionalized nanodiamond delivery system (NPFSSD), which exhibited activated fluorescence and cytotoxicity for doxorubicin [79].…”

Section: Research Progress On Dual-drug-delivery Nano-theranostic Age...mentioning

confidence: 99%

Review of the Application of Dual Drug Delivery Nanotheranostic Agents in the Diagnosis and Treatment of Liver Cancer

Han,

Du,

Zhu

et al. 2023

Molecules

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Liver cancer has high incidence and mortality rates and its treatment generally requires the use of a combination treatment strategy. Therefore, the early detection and diagnosis of liver cancer is crucial to achieving the best treatment effect. In addition, it is imperative to explore multimodal combination therapy for liver cancer treatment and the synergistic effect of two liver cancer treatment drugs while preventing drug resistance and drug side effects to maximize the achievable therapeutic effect. Gold nanoparticles are used widely in applications related to optical imaging, CT imaging, MRI imaging, biomarkers, targeted drug therapy, etc., and serve as an advanced platform for integrated application in the nano-diagnosis and treatment of diseases. Dual-drug-delivery nano-diagnostic and therapeutic agents have drawn great interest in current times. Therefore, the present report aims to review the effectiveness of dual-drug-delivery nano-diagnostic and therapeutic agents in the field of anti-tumor therapy from the particular perspective of liver cancer diagnosis and treatment.

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“…Chemotherapy is currently the primary and most successful mode of tumor therapy in the clinic. 3 In this context, phototherapies like photodynamic treatment (PDT) and photothermal treatment (PTT) have visible encouraging outcomes in the treatment of cancer. Treatment methods that integrate laser light with photosensitizers (PSs) provide great spatial-temporal controllability, low invasiveness, and little medication resistance.…”

Section: Introductionmentioning

confidence: 99%

A comprehensive review on singlet oxygen generation in nanomaterials and conjugated polymers for photodynamic therapy in the treatment of cancer

Singh,

Sen Gupta,

Bose

2024

Nanoscale

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A multifunctional theranostics nanosystem featuring self-assembly of alcohol-abuse drug and photosensitizers for synergistic cancer therapy

Abstract: Conventional treatments for cancer include chemotherapy, surgical resection, radiotherapy have shown limited therapeutic efficacy, such as severe side effects, lack of targeting and drug resistance of monotherapy were limited to...

Cited by 6 publications

References 52 publications

A Novel Nanofiber Hydrogel Adhesive Based on Carboxymethyl Cellulose Modified by Adenine and Thymine

A Novel Nanofiber Hydrogel Adhesive Based on Carboxymethyl Cellulose Modified by Adenine and Thymine

Review of the Application of Dual Drug Delivery Nanotheranostic Agents in the Diagnosis and Treatment of Liver Cancer

A comprehensive review on singlet oxygen generation in nanomaterials and conjugated polymers for photodynamic therapy in the treatment of cancer

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