A comprehensive review on singlet oxygen generation in nanomaterials and conjugated polymers for photodynamic therapy in the treatment of cancer

Singh, Neetika; Sen Gupta, Ria; Bose, Suryasarathi

doi:10.1039/d3nr05801h

Cited by 8 publications

(2 citation statements)

References 170 publications

(226 reference statements)

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“…Cu-doped Ov-Co3O4 as a photosensitizer might possess a photodynamic effect during irradiation. 1 O2 was measured by monitoring the DPBF absorbance at 420 nm [59,60]. As seen in Figure 10b, the fluorescence intensity of pure DPBF and in the presence of bare Ti foils was almost unchanged when placed in the dark for 10 min.…”

Section: Antibacterial Activitymentioning

confidence: 96%

Polydopamine-Coated Copper-Doped Co3O4 Nanosheets Rich in Oxygen Vacancy on Titanium and Multimodal Synergistic Antibacterial Study

Qi,

Yu,

Liu

et al. 2024

Materials

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Medical titanium-based (Ti-based) implants in the human body are prone to infection by pathogenic bacteria, leading to implantation failure. Constructing antibacterial nanocoatings on Ti-based implants is one of the most effective strategies to solve bacterial contamination. However, single antibacterial function was not sufficient to efficiently kill bacteria, and it is necessary to develop multifunctional antibacterial methods. This study modifies medical Ti foils with Cu-doped Co3O4 rich in oxygen vacancies, and improves their biocompatibility by polydopamine (PDA/Cu-Ov-Co3O4). Under near-infrared (NIR) irradiation, nanocoatings can generate •OH and 1O2 due to Cu+ Fenton-like activity and a photodynamic effect of Cu-Ov-Co3O4, and the total reactive oxygen species (ROS) content inside bacteria significantly increases, causing oxidative stress of bacteria. Further experiments prove that the photothermal process enhances the bacterial membrane permeability, allowing the invasion of ROS and metal ions, as well as the protein leakage. Moreover, PDA/Cu-Ov-Co3O4 can downregulate ATP levels and further reduce bacterial metabolic activity after irradiation. This coating exhibits sterilization ability against both Escherichia coli and Staphylococcus aureus with an antibacterial rate of ca. 100%, significantly higher than that of bare medical Ti foils (ca. 0%). Therefore, multifunctional synergistic antibacterial nanocoating will be a promising strategy for preventing bacterial contamination on medical Ti-based implants.

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Section: Antibacterial Activitymentioning

confidence: 96%

Polydopamine-Coated Copper-Doped Co3O4 Nanosheets Rich in Oxygen Vacancy on Titanium and Multimodal Synergistic Antibacterial Study

Qi,

Yu,

Liu

et al. 2024

Materials

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“…Particularly, CPNs doped with energy-acceptor dyes have been synthesized and used in a wide variety of applications. In these doped nanomaterials, the polymeric matrix behaves as an antenna that efficiently collects the excitation energy and funnels it to the energy-acceptor dyes. − This antenna effect enhances the excitation of the dye (amplified excitation), allowing a significant improvement in the efficiency of photocatalytic processes, including the generation of reactive oxygen species (ROS), − which is especially important in applications such as cancer phototherapy and bacterial inactivation.…”

Section: Introductionmentioning

confidence: 99%

Unraveling the Adsorption Mechanism of Rhodamine B onto Conjugated Polymeric Nanoparticles Using Isothermal Calorimetry and Monte Carlo Simulations

Ponzio,

Odella,

Prost

et al. 2024

J. Phys. Chem. C

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We present herein a comprehensive study on the thermodynamics of rhodamine B (RhB) adsorption onto poly(9,9dioctylfluorene-alt-benzothiadiazole) (F8BT) nanoparticles (NPs) dispersed in water using the isothermal calorimetric titration (ITC) technique. ITC experiments were carried out over a wide temperature range (5−65 °C), and the resulting thermograms were subjected to a detailed thermodynamic analysis using different adsorption models. For this purpose, we developed a versatile computational code based on the Monte Carlo method. We found that the thermograms obtained at the different temperatures cannot be interpreted using the Langmuir, bi-Langmuir, or Brunauer, Emmet, Teller (BET) models. However, excellent thermogram fits were attained by applying the Langmuir model coupled with the formation of a RhB dimer on the surface of F8BT NPs. Using this model, the best fit to the experimental data at 25 °C yielded the following parameters for direct RhB adsorption on the F8BT NPs surface: equilibrium constant (K l ) of ∼2 × 10 7 M −1 , enthalpy change (ΔH l ) of ∼1 kJ mol −1 , and entropy change (ΔS l ) of ∼140 J K −1 mol −1 . These results indicate that dye adsorption is predominantly an entropy-controlled process. The fit also provided parameters associated with the formation of a second dye adsorption layer, i.e., the formation of the RhB dimer on the F8BT NPs surface, revealing values of ∼1.7 × 10 5 M −1 , ca. −20 kJ mol −1 , and ∼30 J K −1 mol −1 for K m , ΔH m , and ΔS m , respectively. The latter two parameters are similar to those previously reported for RhB dimer formation in water (ΔH d = −12 kJ mol −1 and ΔS d = 22 J K −1 mol −1 ) supporting the chosen Langmuir-dimer model. The analysis of the thermograms also suggests that the NPs surface available for RhB adsorption is small, as compared to the total surface, and that it decreases with decreasing temperature. The latter observation is intriguing, especially since the F8BT NPs hydrodynamic diameter shows only a small decrease with decreasing temperature. To explain these results, we propose that the surface of the NPs harbors highly hydrated polar groups that reduce the accessibility of the dye for adsorption.

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Three‐in‐One: Molecular Engineering of D–A–π–A Featured Type I and Type II Near‐Infrared AIE Photosensitizers for Efficient Photodynamic Cancer Therapy and Bacteria Killing

Quan,

Pan,

Zhang

et al. 2024

Small

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Bacterial infections are closely correlated with the genesis and progression of cancer, and the elimination of cancer‐related bacteria may improve the efficacy of cancer treatment. However, the combinatorial therapy that utilizes two or more chemodrugs will increase potential adverse effects. Image‐guided photodynamic therapy is a highly precise and potential therapy to treat tumor and microbial infections. Herein, four donor–acceptor–π‐bridge–acceptor (D–A–π–A) featured near‐infrared (NIR) aggregation‐induced emission luminogens (AIEgens) (TQTPy, TPQTPy, TQTC, and TPQTC) with type I and type II reaction oxygen species (ROS) generation capabilities are synthesized. Notably, TQTPy shows mitochondria targeted capacity, the best ROS production efficiency, long‐term tumor retention capacity, and more importantly, the three‐in‐one fluorescence imaging guided therapy against both tumor and microbial infections. Both in vitro and in vivo results validate that TQTPy performs well in practical biomedical application in terms of NIR‐fluorescence imaging‐guided photodynamic cancer diagnosis and treatment. Moreover, the amphiphilic and positively charged TQTPy is able to specific and ultrafast discrimination and elimination of Gram‐positive (G+) Staphylococcus aureus from Gram‐negative (G−) Escherichia coli and normal cells. This investigation provides an instructive way for the construction of three‐in‐one treatment for image‐guided photodynamic cancer therapy and bacteria elimination.

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A comprehensive review on singlet oxygen generation in nanomaterials and conjugated polymers for photodynamic therapy in the treatment of cancer

Abstract: Photodynamic Therapy (PDT): A minimally invasive treatment for a range of benign disorders and malignancies.

Cited by 8 publications

References 170 publications

Polydopamine-Coated Copper-Doped Co3O4 Nanosheets Rich in Oxygen Vacancy on Titanium and Multimodal Synergistic Antibacterial Study

Polydopamine-Coated Copper-Doped Co3O4 Nanosheets Rich in Oxygen Vacancy on Titanium and Multimodal Synergistic Antibacterial Study

Unraveling the Adsorption Mechanism of Rhodamine B onto Conjugated Polymeric Nanoparticles Using Isothermal Calorimetry and Monte Carlo Simulations

Three‐in‐One: Molecular Engineering of D–A–π–A Featured Type I and Type II Near‐Infrared AIE Photosensitizers for Efficient Photodynamic Cancer Therapy and Bacteria Killing

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