A multifunctional SN38-conjugated nanosystem for defeating myelosuppression and diarrhea induced by irinotecan in esophageal cancer

Abstract

Combination of chemotherapy and phototherapy has been proposed as one promising treatment of esophageal cancer (EC). Irinotecan as a first-line treatment option is widely prescribed for metastatic EC, however, its...

Poly(lactic acid)-hyperbranched polyglycerol nanoparticles enhance bioadhesive treatment of esophageal disease and reduce systemic drug exposure

“…For this reason, large solid dosage forms may be less suitable for patients at risk of esophageal strictures. 10,11 Whilst stents are often offered to patients with strictures, whereby the esophageal lumen is opened using a tube or scaffold, [12][13][14] these interventions are invasive and commonly cause complications, such as recurrent dysphagia, pain, and infection. 15,16 Consequently, non-invasive treatments for esophageal disease are highly sought.…”

An Overview of Recent Advancements on Manganese-Based Nanostructures and Their Application for ROS-Mediated Tumor Therapy

“…(b) Synthesis and action mechanism of the FA-PPSM nanocomposites. Reproduced with permission from ref . Copyright 2020, The Royal Society of Chemistry.…”

“…In recent years, our group has done related research on the application of Mn-based NMs to PDT. In 2020, we constructed FA-PDA@PZM/SN38@BSA-MnO 2 (FA-PPSM) as a synergistic chemotherapy//PDT/photothermal therapy (PTT) nanoplatform . In TME, FA-PPSM overcame the resistance associated with hypoxia during PDT by catalyzing endogenous H 2 O 2 to O 2 .…”

“…In 2020, we constructed FA-PDA@PZM/SN38@BSA-MnO 2 (FA-PPSM) as a synergistic chemotherapy//PDT/photothermal therapy (PTT) nanoplatform. 134 In TME, FA-PPSM overcame the resistance associated with hypoxia during PDT by catalyzing endogenous H 2 O 2 to O 2 . At the same time, the reaction product of Mn 2+ can be used for in vivo MRI.…”

Albumin-templated manganese carbonate nanoparticles for precise magnetic resonance imaging of acute myocardial infarction

“…18 However, complicated synthesis procedure or high temperature/pressure is typically involved, and the relaxivities are still lower than the clinically used Gd-DTPA. 19 Until recent years, a simpler and greener method has been developed, that is synthesis of protein-templated Mn nanoparticles, such as MnO 2 @BSA, which displayed easy synthesis process, 20 controllable physical and chemical properties, good solubility 21 and good biocompatibility. 22 However, although some of these nanoparticles did show high r 1 values in acidic conditions, most of their r 1 values in physiological condition (pH = 7.4) are still very low.…”