“…Many reports highlighting the importance for generation of open sites (on activation) in MOF to act as Lewis acid catalyst have been well documented in the literature. 10 In this context, Claisen−Schmidt reaction, 11,12 Knoevenagel condensation, 13−15 epoxidation, 16,17 ring opening of epoxides, 18−21 hydrolysis, 22,23 Friedlander reaction, 24 Friedel−Craft alkylation, 25,26 cyanosilylation, 27−31 acetalization, 32 C−H activation, 33−35 cyclopropanation, 36 Biginelli reactions, 37,38 aldol condensation reaction, 39 Henry reaction, 40,41 carbonyl−ene reaction, 42 Sonogashira reaction, 43 Suzuki coupling, 44 biomass valorization 45,46 cyclization reaction, 47 CO 2 fixation, 48 polymerization, 49 systems, a rational effort in this direction is key for the advancement of this field. The metal-catalyzed nitrene transfer reactions to alkenes affording aziridines, nitrogen analogues of epoxide, are highly valued due to the potential of aziridine to undergo stereo-and regioselective ring-opening transformation forming a wide range of biologically important molecules.…”