A multicenter, randomized, controlled study of the use of nutritional supplements containing collagen peptides to facilitate the healing of pressure ulcers

Yamanaka, Hideharu; Okada, Shingo; Sanada, Hiromi

doi:10.1016/j.jnim.2017.05.001

Cited by 25 publications

(27 citation statements)

References 13 publications

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“…Recently, improvements in stratum corneum hydration and skin elasticity via oral intake of collagen peptides (hydrolyzed collagen) have been reported in young women, 7 – 10 but not in hospitalized older adults. Also, oral nutrition supplements (ONSs) containing collagen peptides have been shown to have therapeutic effects for pressure injuries, 11 but whether they can protect the skin from pressure injuries and other skin problems is unknown. This study examined the effect of an ONS containing collagen peptides on stratum corneum hydration and skin elasticity as measured in the forearms in hospitalized older adults.…”

Section: Introductionmentioning

confidence: 99%

Effect of an Oral Nutrition Supplement Containing Collagen Peptides on Stratum Corneum Hydration and Skin Elasticity in Hospitalized Older Adults: A Multicenter Open-label Randomized Controlled Study

Nomoto¹,

Iizaka

2020

Adv Skin Wound Care

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OBJECTIVE The purpose of this randomized open-label study was to investigate the effect of an oral nutrition supplement containing collagen peptides on stratum corneum hydration and skin elasticity. METHODS The study protocol was registered at the UMIN Clinical Trials Registry (UMIN 000027347). Once-a-day oral administration of a nutrition supplement containing collagen peptides (10.0 g) was instituted in 39 inpatients 65 years or older who were assigned to either the intervention or the control group using a block-randomization design. Stratum corneum hydration and skin elasticity were measured at baseline and at 2, 4, 6, and 8 weeks after the start of the intervention. RESULTS Mean stratum corneum hydration was significantly increased from 43.7 at baseline to 51.7 at postintervention week 8 in the intervention group ( P = .001). Differences in skin elasticity from baseline were significant at postintervention week 6 ( P = .026) and week 8 ( P = .049). CONCLUSIONS Oral nutrition supplements containing collagen peptides may reduce skin vulnerability in older adults and thus prevent conditions such as skin tears.

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Section: Introductionmentioning

confidence: 99%

Effect of an Oral Nutrition Supplement Containing Collagen Peptides on Stratum Corneum Hydration and Skin Elasticity in Hospitalized Older Adults: A Multicenter Open-label Randomized Controlled Study

Nomoto¹,

Iizaka

2020

Adv Skin Wound Care

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“…In human trials with placebo controls, ingestion of collagen hydrolysate (2.5-10 g/day) suppresses transepidermal water loss, reduces wrinkle volume, and increases elasticity of skin [1][2][3][4]. Furthermore, ingestion of collagen hydrolysate moderates the symptoms of 2 of 9 osteoarthritis [5,6] and enhances healing of pressure ulcers [7][8][9]. Our previous work has shown that ingestion of collagen hydrolysate (2-20 g) increases the peptide forms of Hyp (i.e., hydroxyprolyl peptide or collagen peptide) in human peripheral blood plasma to 20-100 µM [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Food-Derived Collagen Peptides, Prolyl-Hydroxyproline (Pro-Hyp), and Hydroxyprolyl-Glycine (Hyp-Gly) Enhance Growth of Primary Cultured Mouse Skin Fibroblast Using Fetal Bovine Serum Free from Hydroxyprolyl Peptide

Asai

Oikawa

Yoshikawa

et al. 2019

IJMS

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Prolyl-hydroxyproline (Pro-Hyp) and hydroxyprolyl-glycine (Hyp-Gly) appear in human blood after ingestion of collagen hydrolysate and trigger growth of fibroblasts attached on collagen gel, which has been associated with beneficial effects upon ingestion of collagen hydrolysate, such as improvement of skin and joint conditions. In the present study, inconsistent results were obtained by using different lots of fetal bovine serum (FBS). Fibroblasts proliferated in collagen gel without adding Pro-Hyp and Hyp-Gly and did not respond to addition of Pro-Hyp and Hyp-Gly, which raises doubts about conclusions from prior research. Unexpectedly high levels of hydroxyprolyl peptides, including Pro-Hyp, however, were present in the FBS (approximately 100 µM), and also in other commercially available forms of FBS (70-80 µM). After removal of low molecular weight (LMW, < 6000 Da) compounds from the FBS by size exclusion chromatography, Pro-Hyp and Hyp-Gly again triggered growth of fibroblasts attached on collagen and increased the number of fibroblasts migrated from mouse skin. These results indicate the presence of bioactive hydroxyprolyl peptides in commercially available FBS, which can mask effects of Pro-Hyp and Hyp-Gly supplementation; our work confirms that Pro-Hyp and Hyp-Gly do play crucial roles in proliferation of fibroblasts.

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“…Pressure ulcers are another chronic wound with several animal studies suggesting that supplementation with collagen hydrolysate improves the healing of pressure ulcers (Nakao et al, 2013 ). Human clinical trials using placebo controls have demonstrated that supplementation with collagen hydrolysate enhances healing of pressure ulcers (Lee et al, 2006 ; Sugihara et al, 2015 , 2018 ; Yamanaka et al, 2017 ). The Japanese Society of Pressure Ulcers Guideline Revision Committee ( 2016 ) has cited collagen hydrolysate in their therapeutic guidelines.…”

Section: Influence Of the Supplementation Of Collagen Peptides On Woumentioning

confidence: 99%

“…However, an in vitro study indicated that p75NTR-negative fibroblasts in healthy tissue did not respond to Pro-Hyp (Asai et al, 2020b ). No adverse effects due to abnormal proliferation of fibroblasts have been observed after long-term administration of collagen hydrolysate in healthy volunteers (Shigemura et al, 2018 ) and pressure ulcer patients (Sugihara et al, 2015 , 2018 ; Yamanaka et al, 2017 ). Thus, supplementation with collagen hydrolysate does not generate severe adverse effects on non-wound tissue.…”

Section: Influence Of the Supplementation Of Collagen Peptides On Woumentioning

confidence: 99%

Collagen-Derived Di-Peptide, Prolylhydroxyproline (Pro-Hyp): A New Low Molecular Weight Growth-Initiating Factor for Specific Fibroblasts Associated With Wound Healing

Satô

Asai

Jimi

2020

Front. Cell Dev. Biol.

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Many cells and soluble factors are involved in the wound healing process, which can be divided into inflammatory, proliferative, and remodeling phases. Fibroblasts play a crucial role in wound healing, especially during the proliferative phase, and show heterogeneity depending on lineage, tissue distribution, and extent of differentiation. Fibroblasts from tissue stem cells rather than from healthy tissues infiltrate wounds and proliferate. Some fibroblasts in the wound healing site express the mesenchymal stem cell marker, p75NTR. In the cell culture system, fibroblasts attached to collagen fibrils stop growing, even in the presence of protein growth factors, thus mimicking the quiescent nature of fibroblasts in healthy tissues. Fibroblasts in wound healing sites proliferate and are surrounded by collagen fibrils. These facts indicate presence of new growth-initiating factor for fibroblasts attached to collagen fibrils at the wound healing site, where the collagen-derived peptide, prolyl-hydroxyproline (Pro-Hyp), is generated. Pro-Hyp triggers the growth of p75NTR-positive fibroblasts cultured on collagen gel but not p75NTR-negative fibroblasts. Thus, Pro-Hyp is a low molecular weight growth-initiating factor for specific fibroblasts that is involved in the wound healing process. Pro-Hyp is also supplied to tissues by oral administration of gelatin or collagen hydrolysate. Thus, supplementation of gelatin or collagen hydrolysate has therapeutic potential for chronic wounds. Animal studies and human clinical trials have demonstrated that the ingestion of gelatin or collagen hydrolysate enhances the healing of pressure ulcers in animals and humans and improves delayed wound healing in diabetic animals. Therefore, the low molecular weight fibroblast growth-initiating factor, Pro-Hyp, plays a significant role in wound healing and has therapeutic potential for chronic wounds.

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A multicenter, randomized, controlled study of the use of nutritional supplements containing collagen peptides to facilitate the healing of pressure ulcers

Cited by 25 publications

References 13 publications

Effect of an Oral Nutrition Supplement Containing Collagen Peptides on Stratum Corneum Hydration and Skin Elasticity in Hospitalized Older Adults: A Multicenter Open-label Randomized Controlled Study

Effect of an Oral Nutrition Supplement Containing Collagen Peptides on Stratum Corneum Hydration and Skin Elasticity in Hospitalized Older Adults: A Multicenter Open-label Randomized Controlled Study

Food-Derived Collagen Peptides, Prolyl-Hydroxyproline (Pro-Hyp), and Hydroxyprolyl-Glycine (Hyp-Gly) Enhance Growth of Primary Cultured Mouse Skin Fibroblast Using Fetal Bovine Serum Free from Hydroxyprolyl Peptide

Collagen-Derived Di-Peptide, Prolylhydroxyproline (Pro-Hyp): A New Low Molecular Weight Growth-Initiating Factor for Specific Fibroblasts Associated With Wound Healing

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