Effect of an Oral Nutrition Supplement Containing Collagen Peptides on Stratum Corneum Hydration and Skin Elasticity in Hospitalized Older Adults: A Multicenter Open-label Randomized Controlled Study

Abstract

OBJECTIVE The purpose of this randomized open-label study was to investigate the effect of an oral nutrition supplement containing collagen peptides on stratum corneum hydration and skin elasticity. METHODS The study protocol was registered at the UMIN Clinical Trials Registry (UMIN 000027347). Once-a-day oral administration of a nutrition supplement containing collagen peptides (10.0 g) was instituted in 39 inpatients 65 years or older who were assigned to either the intervention or the control group using a block-randomization design. Stratum corneum hydration and skin elasticity were measured at baseline and at 2, 4, 6, and 8 weeks after the start of the intervention. RESULTS Mean stratum corneum hydration was significantly increased from 43.7 at baseline to 51.7 at postintervention week 8 in the intervention group ( P = .001). Differences in skin elasticity from baseline were significant at postintervention week 6 ( P = .026) and week 8 ( P = .049). CONCLUSIONS Oral nutrition supplements containing collagen peptides may reduce skin vulnerability in older adults and thus prevent conditions such as skin tears.

Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta‐analysis

“…(2015), Choi et␣al. (2014), and Nomoto and Iizaka (2020), 38–40 and with respect to incomplete data in the results by Nomoto and Iizaka (2020), Proksch et␣al. (2014a), and Schwartz et␣al.…”

“…A methodological assessment of the quality of RoB was performed using the RoB-2 tool. The assessment of RoB at the domain level revealed a low RoB for most studies, as shown in (2019), 17,40,41 as shown in Figure 10.…”

“…The study by Nomoto and Iizaka (2020), which included hospitalized older and unhealthy adults, showed that the intake of HC peptide supplement was beneficial and reduced skin vulnerability to traumatic injuries caused by procedures in bedridden older patients. 40 The effects of HC supplementation on skin recovery after laser treatment were evaluated in the study by Choi et al (2014), and the main results showed an improved healing process in supplemented patients. 39 Most of the selected studies used commercial HC supplementation in ready-to-consume preparations as the intervention (Table 1).…”

“…The study by Nomoto and Iizaka (2020), which included hospitalized older and unhealthy adults, showed that the intake of HC peptide supplement was beneficial and reduced skin vulnerability to traumatic injuries caused by procedures in bedridden older patients 40 . The effects of HC supplementation on skin recovery after laser treatment were evaluated in the study by Choi et␣al.…”

“…Figure 9. At the study level, an RoB was found in the blinding of participants and researchers in the studies by Campos et al (2015), Choi et al (2014), and Nomoto and Iizaka (2020),[38][39][40] and with respect to incomplete data in the results by Nomoto…”