A multicenter, prospective study of fetal outcome following accidental carbon monoxide poisoning in pregnancy

Koren, Gideon; Sharav, Teresa; Pastuszak, Anne; Garrettson, Lorne K.; Hill, Kelly; Samson, Ivan; Rorem, Mark; King, Arlene; Dolgin, Jill

doi:10.1016/0890-6238(91)90002-w

Cited by 108 publications

(27 citation statements)

References 17 publications

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“…Koren's 'Motherisk' group in Toronto published the only prospective multicenter study of CO exposure in pregnant women [37]. They found that pregnancy outcome was adversely affected in 3 of 5 pregnancies in which there was severe toxicity; two stillbirths and one child with cerebral palsy.…”

Section: Human Fetal Exposure To Comentioning

confidence: 99%

“…However, in an elegant and thorough study of volunteers exposed to ambient CO of different concentrations for various lengths of time while sedentary and while exercising, Peterson and Stewart for no difference in COHb concentrations with exercise [42]. Table 1: Severity of CO Exposure used by Koren et al [37].…”

Section: Carbon Monoxide Exposure In Pregnancymentioning

confidence: 99%

“…Some authors have assigned an increasing severity of poisoning based upon symptoms Table 1 [37]. Other authors have stratified poisoning according to blood COHb concentrations.…”

Section: Severity Of Poisoningmentioning

confidence: 99%

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Neurologic and Pregnancy Effects of Carbon Monoxide Exposure

Bird¹

2017

Toxicol Open Access

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Carbon monoxide exposure remains a public health concern worldwide. Despite the burden that carbon monoxide exerts, significant controversy exists regarding optimal treatment of exposed persons. Particular controversy exists around neurologic effects of carbon monoxide exposure, how best to evaluate for neurocognitive dysfunction, and effects on the fetus of pregnant women. This review focuses on the mechanism of injury from carbon monoxide, and summarizes the data regarding neurocognitive dysfunction and fetal effects of exposure.

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Section: Human Fetal Exposure To Comentioning

confidence: 99%

Section: Carbon Monoxide Exposure In Pregnancymentioning

confidence: 99%

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Neurologic and Pregnancy Effects of Carbon Monoxide Exposure

Bird¹

2017

Toxicol Open Access

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“…It is cautioned here that, although some studies have reported major reductions in delayed neurologic sequelae, cerebral oedema, pathologic central nervous system (CNS) changes, and reduced cytochrome oxidase impairment as a result of hyperbaric oxygen therapy, some systematic reviews have not revealed a clear benefit of HBO, so no clear guidelines for its use have been determined. [15,16].…”

Section: Hospital Carementioning

confidence: 99%

“…Fetal CO-Hgb levels cannot be directly measured but can be estimated. Moreover, fetal ultrasound or MRI scan, if available, can be used to check for central nervous system damage and guide further therapy for the new-born if a cesarian section was performed [16].…”

Section: Co Intoxication Treatment In Pregnancymentioning

confidence: 99%

Carbon Monoxide Intoxication: Experiences from Hungary

Gara¹

2017

Poisoning - From Specific Toxic Agents to Novel Rapid and Simplified Techniques for Analysis

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Carbon monoxide (CO) is odorless, colorless, tasteless, and nonirritating gas. Hence, mild CO poisoning often remains unrecognized and appears lethally. Carbon and gas systems, unfavorable architectural designs and machines may also cause intoxications. The prevalence rates in Hungary ranged from 2.37 to 3.80 cases per 100,000 people per year between 2013 and 2015; fatality rates have been decreased from 5.96 in 2013 to 3.38 in 2015. Given the vagueness and the broad spectrum of complaints, misdiagnosis of CO toxicity is common. The gold standard diagnosis is detecting the level of circulating carboxyhemoglobin (CO-Hgb). The measurement of CO-Hgb can be performed via blood-gas analyses or by spectrophotometry. Treatment protocol should follow the ACBDE rule. Administration of 100% oxygen should be performed as soon as possible. Later in-hospital management includes evaluation, treatment and prevention of further peripheral organ damage and long-term neurological complications. Fetuses and children are prone to suffer more severe intoxication due to higher oxygen demand. Though hyperbaric oxygen is the mainstay therapy, a prompt cesarean section is effective in preventing further intoxication. In conclusion, fatal CO intoxication can occur due to plain early signs and symptoms. Hyperbaric oxygen therapy should be considered in severe intoxication, in fetal and children.

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Carbon Monoxide Poisoning Among Recreational Boaters

Hampson¹

1995

JAMA

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A multicenter, prospective study of fetal outcome following accidental carbon monoxide poisoning in pregnancy

Cited by 108 publications

References 17 publications

Neurologic and Pregnancy Effects of Carbon Monoxide Exposure

Neurologic and Pregnancy Effects of Carbon Monoxide Exposure

Carbon Monoxide Intoxication: Experiences from Hungary

Carbon Monoxide Poisoning Among Recreational Boaters

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