A multicenter observational study on the role of comorbidities in the recurrent episodes of benign paroxysmal positional vertigo

Stefano, Alessandro De; Dispenza, Francesco; Suárez, Hamlet; Pérez-Fernández, Nicolas; Manrique-Huarte, Raquel; Ban, Jae Ho; Kim, Min Beom; Strupp, Michael; Feil, Katharina; Oliveira, Carlos Augusto Cardim de; Sampaio, A.L.L.; Araújo, Mercêdes F. S.; Bahmad, Fayez; Ganança, Maurício Malavasi; Ganança, Fernando Freitas; Dorigueto, Ricardo Schaffeln; Lee, Hyung; Kulamarva, Gautham; Mathur, Navneet; Giovanni, Pamela Di; Petrucci, Anna Grazia; Staniscia, Tommaso; Citraro, Leonardo; Croce, A

doi:10.1016/j.anl.2013.07.007

Cited by 107 publications

(118 citation statements)

References 31 publications

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“…In addition to recurrent forms of BPPV induced by surgery, head trauma, or inner ear disease, many factors appear to be related to recurrence, such as advanced age, female gender, osteoporosis, and other systemic disease such as hypertension, diabetes, and depression [7,8]. Our study also revealed that age was a significant factor for BPPV recurrence.…”

Section: Discussionsupporting

confidence: 58%

“…Although BPPV management is well established, the underlying causes of otoconial degeneration and dislodgement from the utricle are not fully known. Several predisposing factors for BPPV have been reported and linked to recurrence, including advanced age, female sex, osteoporosis, trauma, and other inner ear disorders [1,7,19]. Several studies suggested a correlation between BPPV with osteoporosis and vitamin D deficiency, implying that abnormal calcium metabolism may underlie BPPV [4,12,21,27].…”

Section: Introductionmentioning

confidence: 99%

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Bone mineral density and serum 25-hydroxyvitamin D in patients with idiopathic benign paroxysmal positional vertigo

Yang

Kim

Lee

et al. 2018

VES

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Abstract. The aim of this study was to evaluate the relationship between bone mineral density (BMD) and 25-hydroxyvitamin D with the occurrence and recurrence of BPPV. The records of 130 idiopathic BPPV patients (55 ± 12 years old, 30 men and 100 women) and 130 age-and sex-matched controls who underwent bone mineral densitometry between April 2012 and September 2015 were reviewed retrospectively. We compared the BMD and serum 25-hydroxyvitamin D between the patients and controls, and also compared the BMD between recurrent and non-recurrent BPPV groups. Among the female subjects, the BPPV group showed a significantly decreased BMD compared to the controls (p < 0.05). The men in the control group had significantly higher 25-hydroxyvitamin D levels than the men with BPPV (p < 0.05). Sixty-three patients (48%) reported recurrent attacks of BPPV. The women with recurrent BPPV were significantly older and showed a significantly lower BMD than non-recurrent women (p < 0.001). However, multiple regression analysis revealed that age alone was significantly associated with the recurrence of BPPV in women. BMD in women and serum 25-hydroxyvitamin D levels in men are associated with the occurrence of BPPV. Only age is an independent predictor of recurrence, though a low BMD and age correlate with the recurrence of BPPV.

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Section: Discussionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Bone mineral density and serum 25-hydroxyvitamin D in patients with idiopathic benign paroxysmal positional vertigo

Yang

Kim

Lee

et al. 2018

VES

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“…Another study by Yamanaka et al [6] reported a higher incidence of BPPV recurrence (56.3%) in premenopausal woman aged ≥50 years compared to postmenopausal patients with normal bone density (16.1%). The risk of recurrence further increased when patients had two or more underlying comorbidities, such as hypertension, diabetes, or osteoarthrosis [7]. Buki et al [8] reported that patients who were on vitamin D supplementation therapy showed no additional recurrence of BPPV.…”

Section: Discussionmentioning

confidence: 99%

Association of Benign Paroxysmal Positional Vertigo with Osteoporosis and Vitamin D Deficiency – A Case-Control Study

Sen

Padiyar

Arora³

2018

Dubai Med J

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Background: Benign paroxysmal positional vertigo (BPPV) is a common type of vertigo involving the peripheral vestibular system. Consensus on the factors causing BPPV is limited. Due to the uncertainty of etiological factors causing BPPV, most cases are accepted as idiopathic. Calcium metabolism plays a primary role in the synthesis and absorption of otoconia primarily made of calcium carbonate and, thus, might be an etiological factor in the onset of BPPV. Objective: To study the role of osteoporosis and vitamin D deficiency in the etiology of BPPV. Study Design: Case-control study. Methods: This is a case-control study comparing the prevalence of osteoporosis and vitamin D deficiency in 100 patients diagnosed with idiopathic BPPV and 100 hospital-based controls. Mean T scores and serum vitamin D levels were compared in the two groups. The groups were substratified based on age, sex, and menopausal status in order to avoid selection bias. Results: There was a high prevalence of osteoporosis and vitamin D deficiency among the patients with BPPV (60 and 76%, respectively). Postmenopausal patients with BPPV had a significantly higher prevalence of vitamin D deficiency and osteoporosis (57 and 64%, respectively). Conclusion: The prevalence of osteoporosis and vitamin D deficiency is reasonably high in the postmenopausal population. Menopausal patients with suspected BPPV may be empirically treated with vitamin D. However, other known factors causing BPPV should be investigated, and the patients should be treated accordingly.

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“…There is a recent study, De Stefano et al, 2014, where it is possible to demonstrate that hypertension alone influences recurrence and it appears that the presence of comorbidities exposes the patient to an increased risk of relapse of BPPV. 17 In our cases this does not happen probably due to the size of the sample.…”

Section: Discussionmentioning

confidence: 59%

Benign Paroxysmal Positional Vertigo – A Review of 101 Cases

Silva

Amorim

Paiva

2015

Acta Otorrinolaringologica (English Edition)

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A multicenter observational study on the role of comorbidities in the recurrent episodes of benign paroxysmal positional vertigo

Cited by 107 publications

References 31 publications

Bone mineral density and serum 25-hydroxyvitamin D in patients with idiopathic benign paroxysmal positional vertigo

Bone mineral density and serum 25-hydroxyvitamin D in patients with idiopathic benign paroxysmal positional vertigo

Association of Benign Paroxysmal Positional Vertigo with Osteoporosis and Vitamin D Deficiency – A Case-Control Study

Benign Paroxysmal Positional Vertigo – A Review of 101 Cases

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