A multicenter, double-blind, randomized, placebo-controlled study of the efficacy and safety of botulinum toxin type A in the treatment of glabellar lines

Facial aesthetics: is botulinum toxin treatment effective and safe? A systematic review of randomised controlled trials

“…One of the papers suggested injecting into the corrugator muscle 1 cm above the supraorbital ridge and avoiding injecting near the levator palpebrae superioris as precautions to reduce the incidence of blepharoptosis. 12 Headaches and other adverse effects seemed to occur in both the treatment groups and are therefore more likely to be related to the overall effect of the injection procedure than to BTA treatment or other factors.…”

“…After duplicate studies were removed, the above search resulted in a collection of 64 papers refl ecting the use of BTA in the facial area; only seven of these were randomised controlled trials that compared the use of BTA over placebo in facial aesthetics. [11][12][13][14][15][16][17] Full-length articles of these 64 papers were obtained and assisted in a hand search to locate any other randomised controlled trials comparing BTA to a placebo in facial aesthetics. The hand search resulted in a further four double-blind RCTs to be included in our study.…”

“…[12][13][14]17 In the fi rst paper, blepharoptosis was resolved with an average duration of 20-40 days. 12 In the second paper, the incidence of blepharoptosis was 1% and classifi ed as mild, but there was no mention of how soon it was resolved.…”

“…[12][13][14]17 In the fi rst paper, blepharoptosis was resolved with an average duration of 20-40 days. 12 In the second paper, the incidence of blepharoptosis was 1% and classifi ed as mild, but there was no mention of how soon it was resolved. 13 The third paper had a very low incidence of blepharoptosis affecting 1 in 73 patients (0.01%) that started 13 days after injections, was considered mild, had improved by week four and was not visible by week 12.…”

Efeitos adversos associados à aplicação de toxina botulínica na face: revisão sistemática com meta-análise

“…Após este processo de seleção, 21 estudos (13 relatos de casos (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27) , não randomizados, não cegos e sem controle; e 8 ensaios clínicos randomizados (28)(29)(30)(31)(32)(33)(34)(35) , satisfizeram os critérios de inclusão deste estudo. Detalhes do processo de inclusão e exclusão dos estudos estão dispostos na figura 1.…”