Iodoform (triiodomethane), a yellow crystalline solid, belonging to the family of organic halogen compounds, is used as an antiseptic. Its antiseptic action is due to the slow release of iodine under the action of catalase from wounds. Currently, it is widely used only in dentistry and in veterinary medicine. We have extended, with good results, the use of iodoform as an antiseptic for other types of surgical or traumatic wounds that have been infected with piogens. Between 2009 and 2018, on 242 cases of different wounds, we obtained good results, with no severe adverse effects.