A multi-strain probiotic blend reshaped obesity-related gut dysbiosis and improved lipid metabolism in obese children

Abstract

Background and aimsObese children are more prone to becoming obese adults, and excess adiposity consequently increases the risk of many complications, such as metabolic syndromes, non-alcoholic fatty liver disease, cardiovascular disease, etc. This study aimed to evaluate the effects of multi-strain probiotics on the gut microbiota and weight control in obese children.MethodsA double-blind, randomized, placebo-controlled trial was carried out on overweight and obese children. Subjects received 12 weeks of treatment with supplementary probiotics that contained three strains: Lactobacillus salivarius AP-32, L. rhamnosus bv-77, and Bifidobacterium animalis CP-9, plus diet and exercise guidance. A total of 82 children were enrolled, and 53 children completed the study.ResultsThe supplementation of multi-strain probiotics resulted in a significant effect demonstrating high-density lipoprotein (HDL) and adiponectin elevation. At the same time, body mass index (BMI) and serum total cholesterol, low-density lipoprotein (LDL), leptin, and tumor necrosis factor-alpha (TNF-α) levels were reduced. Lactobacillus spp. and B. animalis were particularly increased in subjects who received probiotic supplements. The abundance of Lactobacillus spp. was inversely correlated with the ether lipid metabolism pathway, while that of B. animalis was positively correlated with serum adiponectin levels.ConclusionOur results show that obesity-related gut dysbiosis can be reshaped by the supplementation of a multi-strain probiotic to improve lipid metabolism. The regular administration of a multi-strain probiotic supplement may be helpful for weight control and health management in overweight and obese children.

Evaluation of the Feasibility of In Vitro Metabolic Interruption of Trimethylamine with Resveratrol Butyrate Esters and Its Purified Monomers

“…Interestingly, probiotic/prebiotic applications performed in human clinical and animal models effectively enhanced the abundance of probiotics in the intestines and significantly reduced TMA and TMAO metabolism, accompanied by other benefits such as decreased body weight, lipids, and cholesterol marker levels [ 52 , 54 , 55 ]. Probiotic supplementation alone completes the regulation of the gut microbiota, with improved lipid profiles and reduced inflammation [ 56 , 57 , 58 , 59 ].…”

Microbiome‐modulating nutraceuticals ameliorate dyslipidemia in type 2 diabetes: A systematic review, meta‐analysis, and meta‐regression of clinical trials

“…Further, from a metaanalysis of 13 trials (818 T2D participants), Liang et al 114 highlight their safety profile in children and pregnant women. [115][116][117] Cardiovascular disease (CVD) affects one in three and kills one in two T2D patients. 118 CVD accounts for 20%-49% of the total cost of treating a T2D patient with comorbid cardiovascular complications.…”

Exploring a novel therapeutic strategy: the interplay between gut microbiota and high-fat diet in the pathogenesis of metabolic disorders

“…Gut microbiota can influence the efficiency of energy acquisition from digested nutrients and fat storage in the body. By transferring fecal microbiota transplantation to the host or feeding probiotics, obesity phenotype indicators can be improved, and the levels of HDL-C, LDL-C, adiponectin, leptin, and TNF-α can be regulated ( 116 , 119 – 121 ). Animal experiments have also found that obese mice receiving microbiota from post-bariatric surgery mice showed enrichment of mucin-degrading Akkermansia muciniphila or Bacteroides fragilis , increased levels of tryptophan-derived metabolites, SCFAs, and acylcarnitines, increased brown fat mass and activity, increased energy expenditure, and improved immune homeostasis in white adipose tissue ( 122 ).…”