A multi-functional MgF2/polydopamine/hyaluronan-astaxanthin coating on the biodegradable ZE21B alloy with better corrosion resistance and biocompatibility for cardiovascular application

Hou, Yachen; Zhang, Xueqi; Li, Jingan; Wang, Liguo; Guan, Shaokang

doi:10.1016/j.jma.2022.06.008

Cited by 17 publications

(7 citation statements)

References 51 publications

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“…However, as the concentration of GA-PEPE increased to 25 and 50 μM, the cell viability of raw264.7 was significantly reduced ( p < 0.0001). Around the experimental group at the lowest three concentrations, the results of cell live and death staining were used to compensate for the shortcomings of CCK8 experiment Figure B–D shows the results of the cell staining.…”

Section: Resultsmentioning

confidence: 99%

“…Around the experimental group at the lowest three concentrations, the results of cell live and death staining were used to compensate for the shortcomings of CCK8 experiment. 67 Figure 6 B–D shows the results of the cell staining. Relatively significant cell death was observed in GA-PEPE at 12.5 μM compared to the control group, while the degree of cell death in PEPE at 3.125 μM was lower than that in CCK8.…”

Section: Resultsmentioning

confidence: 99%

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Gallic Acid-Modified Polyethylenimine–Polypropylene Carbonate–Polyethylenimine Nanoparticles: Synthesis, Characterization, and Anti-Periodontitis Evaluation

Xie,

Gao,

Liu

et al. 2024

ACS Omega

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The aim of the research was to develop novel gallic acid (GA)-modified amphiphilic nanoparticles of polyethylenimine (PEI)−polypropylene carbonate (PPC)−PEI (PEPE) and comprehensively assess its properties as an antiperiodontitis nanoparticle targeting the Toll-like receptor (TLR). The first step is to evaluate the binding potential of GA to the core trigger receptors TLR2 and TLR4/MD2 for periodontitis using molecular docking techniques. Following this, we conducted NMR, transmission electron microscopy, and dynamic light scattering analyses on the synthesized PEPE nanoparticles. As the final step, we investigated the synthetic results and in vitro antiperiodontitis properties of GA-PEPE nanoparticles. The investigation revealed that GA exhibits potential for targeted binding to TLR2 and the TLR4/MD2 complex. Furthermore, we successfully developed 91.19 nm positively charged PEPE nanoparticles. Spectroscopic analysis indicated the successful synthesis of GA-modified PEPE. Additionally, CCK8 results demonstrated that GA modification significantly reduced the biotoxicity of PEPE. The in vitro antiperiodontitis properties assessment illustrated that 6.25 μM of GA-PEPE nanoparticles significantly reduced the expression of pro-inflammatory factors TNF-α, IL-1β, and IL-6. The GA-PEPE nanoparticles, with their targeted TLR binding capabilities, were found to possess excellent biocompatibility and antiperiodontitis properties. GA-PEPE nanoparticles will provide highly innovative input into the development of anti-periodontitis nanoparticles.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Gallic Acid-Modified Polyethylenimine–Polypropylene Carbonate–Polyethylenimine Nanoparticles: Synthesis, Characterization, and Anti-Periodontitis Evaluation

Xie,

Gao,

Liu

et al. 2024

ACS Omega

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“…Mg alloys and their degradation products can partially reduce endothelial proliferation, and bioresorbable Mg stents exhibit negative charges during degradation [ 51 ], which may possess potential antithrombotic properties. Studies have also demonstrated that Mg can attenuate ischemia–reperfusion injury [ 52 ], and its inhibition of endothelin-1 production can prevent endothelin-mediated vasoconstriction [ 53 , 54 ]. Bioresorbable Mg scaffolds in the field of coronary stents are still undergoing advancements.…”

Section: Types Of Mg-based Supportsmentioning

confidence: 99%

Research on the Current Application Status of Magnesium Metal Stents in Human Luminal Cavities

Chen,

Xia,

Shen

et al. 2023

JFB

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The human body comprises various tubular structures that have essential functions in different bodily systems. These structures are responsible for transporting food, liquids, waste, and other substances throughout the body. However, factors such as inflammation, tumors, stones, infections, or the accumulation of substances can lead to the narrowing or blockage of these tubular structures, which can impair the normal function of the corresponding organs or tissues. To address luminal obstructions, stenting is a commonly used treatment. However, to minimize complications associated with the long-term implantation of permanent stents, there is an increasing demand for biodegradable stents (BDS). Magnesium (Mg) metal is an exceptional choice for creating BDS due to its degradability, good mechanical properties, and biocompatibility. Currently, the Magmaris® coronary stents and UNITY-BTM biliary stent have obtained Conformité Européene (CE) certification. Moreover, there are several other types of stents undergoing research and development as well as clinical trials. In this review, we discuss the required degradation cycle and the specific properties (anti-inflammatory effect, antibacterial effect, etc.) of BDS in different lumen areas based on the biocompatibility and degradability of currently available magnesium-based scaffolds. We also offer potential insights into the future development of BDS.

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“…Surface self-assembly was the main method to prepare ECM component coatings on the surface of cardiovascular materials for a long time in the past, especially since the LbL self-assembly technology can make the ECM coating more evenly distributed on the surface, but its disadvantage is that with the increase in different layers, the stability of the coating will gradually decline at a turning point [61]. In comparison, it is simpler and more stable for different ECM components to be blended and self-assembled to the material surface as required [62]. The distribution, morphology and behavior of cells on the surface can be controlled by stamping ECM components onto the surface of materials with polymer stamps.…”

Section: Preparation Of Ecmmentioning

confidence: 99%

Extracellular Matrix Coatings on Cardiovascular Materials—A Review

et al. 2022

Self Cite

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Vascular transplantation is an effective and common treatment for cardiovascular disease (CVD). However, the low biocompatibility of implants is a major problem that hinders its clinical application. Surface modification of implants with extracellular matrix (ECM) coatings is an effective approach to improve the biocompatibility of cardiovascular materials. The complete ECM seems to have better biocompatibility, which may give cardiovascular biomaterials a more functional surface. The use of one or several ECM proteins to construct a surface allows customization of coating composition and structure, possibly resulting in some unique functions. ECM is a complex three-dimensional structure composed of a variety of functional biological macromolecules, and changes in the composition will directly affect the function of the coating. Therefore, understanding the chemical composition of the ECM and its interaction with cells is beneficial to provide new approaches for coating surface modification. This article reviews novel ECM coatings, including coatings composed of intact ECM and biomimetic coatings tailored from several ECM proteins, and introduces new advances in coating fabrication. These ECM coatings are effective in improving the biocompatibility of vascular grafts.

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A multi-functional MgF2/polydopamine/hyaluronan-astaxanthin coating on the biodegradable ZE21B alloy with better corrosion resistance and biocompatibility for cardiovascular application

Cited by 17 publications

References 51 publications

Gallic Acid-Modified Polyethylenimine–Polypropylene Carbonate–Polyethylenimine Nanoparticles: Synthesis, Characterization, and Anti-Periodontitis Evaluation

Gallic Acid-Modified Polyethylenimine–Polypropylene Carbonate–Polyethylenimine Nanoparticles: Synthesis, Characterization, and Anti-Periodontitis Evaluation

Research on the Current Application Status of Magnesium Metal Stents in Human Luminal Cavities

Extracellular Matrix Coatings on Cardiovascular Materials—A Review

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