A Multi-Center, Cross-Sectional Study on the Burden of Infectious Keratitis in China

Song, Xiusheng; Xie, Liping; Tan, Xiaodong; Wang, Zhichong; Yang, Yanning; Yuan, Yuansheng; Deng, Yao; Fu, Shaoying; Xu, Jianjiang; Sun, Xing‐Guo; Sheng, Xunlun; Wang, Qing

doi:10.1371/journal.pone.0113843

Cited by 68 publications

(52 citation statements)

References 21 publications

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“…Corneal ulcer is the most frequently-occurred symptom in corneal diseases 1 . A corneal ulcer is an inflammatory or more seriously, infective condition of the cornea involving disruptions of its epithelial layer or the corneal stroma 2,3 .…”

Section: Background and Summarymentioning

confidence: 99%

The SUSTech-SYSU dataset for automatically segmenting and classifying corneal ulcers

et al. 2020

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Corneal ulcer is a common ophthalmic symptom. Segmentation algorithms are needed to identify and quantify corneal ulcers from ocular staining images. Developments of such algorithms have been obstructed by a lack of high quality datasets (the ocular staining images and the corresponding goldstandard ulcer segmentation labels), especially for supervised learning based segmentation algorithms. In such context, we prepare a dataset containing 712 ocular staining images and the associated segmentation labels of flaky corneal ulcers. In addition to segmentation labels for flaky corneal ulcers, we also provide each image with three-fold class labels: firstly, each image has a label in terms of its general ulcer pattern; secondly, each image has a label in terms of its specific ulcer pattern; thirdly, each image has a label indicating its ulcer severity degree. This dataset not only provides an excellent opportunity for investigating the accuracy and reliability of different segmentation and classification algorithms for corneal ulcers, but also advances the development of new supervised learning based algorithms especially those in the deep learning framework.

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Section: Background and Summarymentioning

confidence: 99%

The SUSTech-SYSU dataset for automatically segmenting and classifying corneal ulcers

et al. 2020

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“…The ocular surface is susceptible to infection, inflammation, trauma and other ocular surface diseases that strongly affect people's health and quality of life [1][2][3]. Various clinical symptoms may exist for most of the ocular surface diseases.…”

Section: Introductionmentioning

confidence: 99%

Multi-modal Anterior Eye Imager Combining Ultra-High Resolution OCT and Microvascular Imaging for Structural and Functional Evaluation of the Human Eye

et al. 2020

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To establish complementary information for the diagnosis and evaluation of ocular surface diseases, we developed a multi-modal, non-invasive optical imaging platform by combining ultra-high resolution optical coherence tomography (UHR-OCT) with a microvascular imaging system based on slit-lamp biomicroscopy. Our customized UHR-OCT module achieves an axial resolution of ≈2.9 µm in corneal tissue with a broadband light source and an A-line acquisition rate of 24 kHz with a line array CCD camera. The microvascular imaging module has a lateral resolution of 3.5 µm under maximum magnification of ≈187.5× with an imaging rate of 60 frames/s, which is sufficient to image the conjunctival vessel network and record the movement trajectory of clusters of red blood cells. By combining the imaging optical paths of different modules, our customized multi-modal anterior eye imaging platform is capable of performing real-time cross-sectional UHR-OCT imaging of the anterior eye, conjunctival vessel network imaging, high-resolution conjunctival blood flow videography, fluorescein staining and traditional slit-lamp imaging on a single device. With self-developed software, a conjunctival vessel network image and blood flow videography were further analyzed to acquire quantitative morphological and hemodynamics parameters, including vessel fractal dimensions, blood flow velocity and vessel diameters. The ability of our multi-modal anterior eye imager to provide both structural and functional information for ophthalmic clinical applications was demonstrated on a healthy human subject and a keratitis patient. evaluation of ocular surface diseases, different imaging modalities are usually applied in ophthalmic clinics to provide multi-modal and multi-dimensional images [7,8].Slit-lamp biomicroscopy (SLB) is the gold standard for routine ophthalmic examinations. By shining a thin sheet of light into the eye, an in vivo stereoscopic evaluation of the pathological changes of the cornea, conjunctiva and other anterior segment tissues can be performed by SLB [9]. However, the limited magnification and poor spatial resolution of traditional SLB make it difficult to visualize more detailed pathological structures and perform accurate biometric measurements [10][11][12]. Fluorescein stain could stain stroma while leaving the intact epithelium with a specific fluorescein dye, thereby demarcating the location and area of the epithelial loss in ocular surface diseases, on a relative macro scale as well [13]. Developed in the 1990s, optical coherence tomography (OCT) has revolutionized the field of ophthalmology and vision science with its non-contact, non-invasive and high-resolution nature and become one of the prominent diagnostic tools in offering cross-sectional tissue imaging [14][15][16]. Applications of OCT for in vivo human eye imaging have been widely demonstrated in the literature [17][18][19][20][21][22][23][24][25][26][27][28]. With ever-improving techniques in broadband light sources, ultra-high resolution OCT (UHR-OCT) has achieved m...

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“…[15–17] A national, multicenter, epidemiological survey organized by the Shangdong Eye Institute in 2010 showed that the prevalence of infectious keratitis was 19.2/10,000 individuals, and the prevalence of HSK was 11.0/10,000 individuals, ranking first in infectious keratitis in China. [18] In summary, HSK is a major cause of corneal blindness worldwide, and more studies concerning the prevention and rehabilitation of infectious corneal blindness should be conducted, in this study we applied DALK using GCCTs for management of HSK.…”

Section: Discussionmentioning

confidence: 99%

Clinical evaluation of deep anterior lamellar keratoplasty using glycerol-cryopreserved corneal tissues for refractory herpetic stromal keratitis

et al. 2016

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The study aimed to evaluate the therapeutic effects of deep anterior lamellar keratoplasty (DALK) using glycerol-cryopreserved corneal tissues (GCCTs) in patients with refractive herpes simplex keratitis (HSK). This article was a retrospective, noncomparative, and interventional case series. Patients with HSK underwent DALK using GCCTs at Shanghai Tongji Hospital from 2012 to 2015. The best spectacle corrected visual acuity, recurrent inflammation, graft status, postoperative central graft thickness, and pre/postoperative complications were detected. The follow-up ranged from 24.4 ± 5.6 months (range: 16–38 months). Overall, the best spectacle corrected visual acuity was increased from HM/10 cm to 0.15 before surgery to 0.41 ± 0.14 (range: 0.1–0.8; P < 0.05) at 12 months postoperatively. Intraoperative microperforation occurred in 4 eyes (14.81%), and rejection episodes were encountered in 3 of 27 eyes (11.1%), and all of the eyes reversed. HSK recurred in 2 eyes (7.41%), 1 eye with repeated recurring HSK, and eventually led to perpetual corneal opacity and the patient refused a retransplantation. The mean entire corneal thickness was 0.519 ± 0.018 mm (range: 0.5–0.56 mm) and the mean graft thickness was 0.405 ± 0.033 mm (range: 0.35–0.47 mm) in the final follow-up. The DALK using GCCTs was proven to be an effective and safe therapy in treating refractory HSK.

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A Multi-Center, Cross-Sectional Study on the Burden of Infectious Keratitis in China

Cited by 68 publications

References 21 publications

The SUSTech-SYSU dataset for automatically segmenting and classifying corneal ulcers

The SUSTech-SYSU dataset for automatically segmenting and classifying corneal ulcers

Multi-modal Anterior Eye Imager Combining Ultra-High Resolution OCT and Microvascular Imaging for Structural and Functional Evaluation of the Human Eye

Clinical evaluation of deep anterior lamellar keratoplasty using glycerol-cryopreserved corneal tissues for refractory herpetic stromal keratitis

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