A Morphologic and Quantitative Study of Mechanoreceptors in the Remnant Stump of the Human Anterior Cruciate Ligament

Gao, Feng; Zhou, Jingjiao; He, Chen; Ding, Jie; Lou, Zhikun; Xie, Qiang; Li, Haiwei; Li, Fangxiang; Li, Guoping

doi:10.1016/j.arthro.2015.07.010

Cited by 54 publications

(44 citation statements)

References 30 publications

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“…[22] found a significant decrease in the number of mechanoreceptors in the ACL stump with increasing duration of injury, which is different from our study. However, they used S-100 instead of NFP staining.…”

Section: Discussioncontrasting

confidence: 99%

“…3Comparison of number of mechanoreceptors over a graded time period for our study versus that of Sha et al. [22] …”

Section: Discussionmentioning

confidence: 99%

“…First of all, complete harvesting of the specimen was done as close to the attachment as possible in our study, as opposed to some other studies in which the whole residual stump was not harvested. Secondly, most of the other authors using indirect methods applied the S-100 staining method [1, 15, 21, 22]. This method has been proved to stain free nerve endings significantly, but whether these nerve endings have any proprioceptive function remains to be determined [1].…”

Section: Discussionmentioning

confidence: 99%

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Quantitative correlation of mechanoreceptors in tibial remnant of ruptured human anterior cruciate ligament with duration of injury and its significance: an immunohistochemistry-based observational study

et al. 2018

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BackgroundProprioception is a specialized sensory modality encompassing the movement of the joint and its position in space. Reconstruction of the anterior cruciate ligament (ACL) does not always yield expected outcome, suggesting that successful reconstruction depends on not only the ultimate strength of the graft but also recovery of proprioception. Treatment delay is a significant concern in developing countries, e.g., in Asia. Thus, presence of mechanoreceptors is one of the factors having paramount importance for successful outcome. We conducted this study to identify mechanoreceptors via immunohistochemical staining and correlate their presence with duration of injury.Materials and methodsA total of 38 injured native ACL stumps were harvested from patients undergoing ACL reconstruction and stained with neurofilament protein stain to detect functional mechanoreceptors.ResultsOf the specimens, 44.7% stained positive for monoclonal antibody. No association was found between duration of injury and presence of mechanoreceptors (p = 0.897). No correlation was seen between age and side.ConclusionsNo correlation was found between duration of injury and presence of viable mechanoreceptors, hence it is beneficial to preserve the native ACL stump irrespective of the time interval between injury and surgery.Level of EvidenceIII.

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Section: Discussioncontrasting

confidence: 99%

“…3Comparison of number of mechanoreceptors over a graded time period for our study versus that of Sha et al. [22] …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Quantitative correlation of mechanoreceptors in tibial remnant of ruptured human anterior cruciate ligament with duration of injury and its significance: an immunohistochemistry-based observational study

et al. 2018

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“…A previous study reported that the mechanoreceptors that are found in the ACL remnant may contribute to the proprioception of the knee [9] and provide some biomechanical stability of the knee [10]. An immunohistochemical study [11] on the morphology and the quantity of mechanoreceptors in 40 ACL reconstruction patients shows that the time from injury to surgery was negatively correlated with the number of total mechanoreceptors (r = −0.52, p < 0.01). This study emphasizes the role of the ACL stump or ACL remnant that has a role in the preservation of proprioceptive functions of the knee.…”

Section: The Anatomic Single-bundle Anterior Cruciate Ligament Reconsmentioning

confidence: 96%

Anatomic Single-Bundle ACL Reconstruction with Remnant Augmentation Technique

Apivatgaroon¹

2018

Recent Advances in Arthroscopic Surgery

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Anterior cruciate ligament (ACL) injury is the common ligamentous injury of the knees. An ACL reconstruction is the procedure that has been proven to improve knee stability and functional outcomes and may prevent the osteoarthritic changes and subsequent meniscal injuries. The ACL reconstruction techniques have been developed in various ways. Anatomical single-bundle ACL reconstruction with remnant augmentation technique is the optimal reconstruction procedure. It may improve the clinical outcomes of biological healing, preserve the proprioceptive function, and has shown less tibial tunnel widening postoperatively. This chapter presents the step-by-step technique of an anatomical single-bundle ACL reconstruction, indication and contraindication for surgery, the preferred graft choice, fixation methods, pearls and pitfalls of the procedure, and postoperative rehabilitation. The review of literatures about the remnant preserving ACL reconstruction is also discussed in this chapter.

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“…A morphologic and quantitative study of mechanoreceptors in the remnant stump of the human ACL suggests that the time from injury to surgery (log10 days) was negatively correlated with the number of total mechanoreceptors. 17 …”

Section: Significance Of Acl Remnant Preservation and Proprioception mentioning

confidence: 99%

Anterior cruciate ligament remnant and its values for preservation

Muneta

Koga

2017

Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilit

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Controversy surrounds the remnant-preserving anterior cruciate ligament surgery. Advantages of remnant preservation have been reported in regard to better healing and knee function, although no consensus has been reached. This review article discussed the value and meaning of anterior cruciate ligament remnant preservation in several sections such as effects on healing, remnant classification, biomechanical evaluation, relation to proprioception, animal studies, and clinical studies. We hope that this review will facilitate further discussion and investigation for better treatment of anterior cruciate ligament injuries. So far, the current reviews have not provided sufficient scientific evidence to support the value of preserving the remnant.

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A Morphologic and Quantitative Study of Mechanoreceptors in the Remnant Stump of the Human Anterior Cruciate Ligament

Cited by 54 publications

References 30 publications

Quantitative correlation of mechanoreceptors in tibial remnant of ruptured human anterior cruciate ligament with duration of injury and its significance: an immunohistochemistry-based observational study

Quantitative correlation of mechanoreceptors in tibial remnant of ruptured human anterior cruciate ligament with duration of injury and its significance: an immunohistochemistry-based observational study

Anatomic Single-Bundle ACL Reconstruction with Remnant Augmentation Technique

Anterior cruciate ligament remnant and its values for preservation

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