A mononuclear Co(II) complex: Crystal structure, thermal behavior, optical properties and biological activities

The present investigation goal was to investigate the chemistry of four new mononuclear mixed ligand Fe(III), Co(II), Cu(II), and Cd(II) complexes constructed from furfural-type imine ligand (L), and the co ligand 2,2′-bipyridine in addition to assessing their antimicrobial activity against some bacterial, and fungi strains. The structure of the complexes was interpreted by different spectroscopic techniques such as MS, IR, 1H NMR, UV–Vis, elemental analysis, TG-DTG, conductivity, and magnetic susceptibility measurements. The correlation of all results revealed that ligand (L) acts as a neutral ONNO tetradentate whereas the co ligand acts as a neutral NN bidentate. The coordination of the ligands with the metal ions in a molar ratio of 1:1:1 leads to formation of an octahedral geometry around the metal ions. The octahedral geometry has been validated and optimized by DFT analysis. Conductivity data showed the electrolytic nature of all complexes. The thermal stability of all complexes was deduced in addition to evaluating some thermodynamic, and kinetic parameters using Coats–Redfern method. Furthermore, all complexes in comparison to their parent ligands were tested for their biological potency against some pathogenic bacterial, and fungi strains using the paper disk diffusion method. [CdL(bpy)](NO3)2 complex revealed the highest antimicrobial activity.

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“…The absorption coefficient (α, cm −1 ) is evaluated at first using the data of absorbance (A) and thickness (t) as given in Eq. ( 1 ) 43 . …”

Section: Resultsmentioning

confidence: 99%

Synthesis, structural characterization, and antimicrobial evaluation of new mononuclear mixed ligand complexes based on furfural-type imine ligand, and 2,2′-bipyridine

Ismail

El–Wahab

Ali

et al. 2023

Sci Rep

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“…In the third stage of degradation, mass loss of the non-coordinated part of the ligand is observed at 62.08% (Calc. 62.04%) at ~450 °C and finally, the TG curve attains a horizontal level corresponding to the formation of stable metal oxide (½Cr2O3) [29,30].…”

Section: Thermogravimetric Analysismentioning

confidence: 99%

A heterocyclic N'-(4-(diethylamino)-2-hydroxybenzylidene)-4-oxopiperidine-1-carbohydrazide Schiff base ligand and its metal complexes: Synthesis, structural characterization, thermal behavior, fluorescence properties, and biological activities

Dongare

Aswar

2022

Eur J Chem

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A new heterocyclic hydrazone Schiff base ligand, N'-(4-(diethylamino)-2-hydroxy benzylidene)-4-oxopiperidine-1-carbohydrazide, (H2L) was derived by a condensation reaction of 4-oxopiperidine-1-carbohydrazide with 4-(diethylamino)-2-hydroxybenz-aldehyde. The ligand reacts with chloride salts of chromium(III), manganese(II), iron(III), cobalt(II), nickel(II), copper(II) and zinc(II) to form metal complexes of [Cr(L)(Cl)(H2O)2], [Mn(HL)(Cl)(H2O)2], [Fe(L)(Cl)(H2O)2], [Co(HL)(Cl)(H2O)2], [Ni(HL)(Cl)(H2O)2], [Cu(HL)(Cl) (H2O)2], [Zn(L)(H2O)], respectively. The structure of the hydrazone ligand was confirmed by elemental analysis and spectroscopic techniques, viz., FT-IR, 1H NMR, 13C NMR, and LC-MS spectroscopy. The newly synthesized ligand behaves as a tridentate ONO donor towards Cr, Mn, Fe, Co, Ni, Cu, and Zn metal ions. The spectral, magnetic moment, and thermal data indicate the octahedral geometry for all metal complexes except for Zn, which has tetrahedral geometry with 1:1 stoichiometry (M:L). ESR study revealed that π-bonding covalency is much stronger than the σ-bonding with axial distortion in the structure. The molar conductivity data suggested the nonelectrolytic nature of the complexes. The powder X-ray diffraction patterns suggest the nanocrystalline nature of the compounds. The SEM micrograph of the ligand significantly differs from its Ni(II) complex indicating coordination of Ni(II) ion to the ligand. The intense fluorescence emitted in the region of λExcitation 521 to 524 nm due to the functional fluorophores of the ligand and its manganese (II), chromium(III), cobalt(II), and zinc(II) complexes. Various kinetic parameters such as Ea, ∆S, ∆H, and ∆G of various decomposition steps were calculated from TGA diagrams using Coats-Redfern method and the thermal stability order was found to be Cr < Fe < Co < Mn = Cu < Zn < Ni. The antibacterial and antifungal activities of the ligand and its divalent and trivalent metal complexes were performed against the various pathogens viz. Escherichia coli, Salmonella typhi, Staphylococcus aureus, Bacillus subtilis, Candida albicans, and Aspergillus niger with reference to standard antibiotics viz. ofloxacin, azithromycin, and fluconazole. All metal complexes showed promising biological activity as compared with their parent ligand and may be used as a potential antimicrobial candidate in biological science.

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“…Интерес современных ученых в первую очеред, связан с их высоким синтетическим потенциалом и разнообразием свойств. Одним из таких классов можно выделить галогенидные комплексы меди(II) и кобальта(II) анионного типа состава Ln[МHal4] [1][2][3][4][5][6][7][8][9]. В качестве органического катиона (L + ) рассматриваются азотсодержащие гетероциклические соединения -производные азолов: пиридина, пиразола, пиримидина и т.д.…”

Section: аннотация разработаны методики синтеза новых тетрагалогенидн...unclassified

Study of New Halide’s Copper(ii) and Cobalt(ii) Complex With 2-Amino-5-Bromo-3-Methyl Pyridine: Synthesis, Structure, Properties

Protsenko,

Shulyak,

Protsenko

et al. 2023

Vestn. Kuzbasskogo gos. teh. univ.

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A mononuclear Co(II) complex: Crystal structure, thermal behavior, optical properties and biological activities

Cited by 13 publications

References 66 publications

Synthesis, structural characterization, and antimicrobial evaluation of new mononuclear mixed ligand complexes based on furfural-type imine ligand, and 2,2′-bipyridine

Synthesis, structural characterization, and antimicrobial evaluation of new mononuclear mixed ligand complexes based on furfural-type imine ligand, and 2,2′-bipyridine

A heterocyclic N'-(4-(diethylamino)-2-hydroxybenzylidene)-4-oxopiperidine-1-carbohydrazide Schiff base ligand and its metal complexes: Synthesis, structural characterization, thermal behavior, fluorescence properties, and biological activities

Study of New Halide’s Copper(ii) and Cobalt(ii) Complex With 2-Amino-5-Bromo-3-Methyl Pyridine: Synthesis, Structure, Properties

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