A Monolithically Integrated Pressure/Oxygen/Temperature Sensing SoC for Multimodality Intracranial Neuromonitoring

Chan, Wai Pan; Narducci, Margarita; Gao, Yuan; Cheng, M.; Cheong, Jia Hao; George, Arup K.; Cheam, Daw Don; Leong, Siew Chong; Damalerio, Maria Ramona B.; Lim, Ruiqi; Tsai, Ming-Jen; Rahman, Abdur; Park, Mi Kyoung; Kong, Zhi Hui; Prashanth, R; Je, Minkyu

doi:10.1109/jssc.2014.2345754

Cited by 31 publications

(7 citation statements)

References 23 publications

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“…Photolithographic patterning and dry etching were then used to accurately define the membrane areas across the wafer. Together this novel combination of processes significantly improved manufacturability compared to previously described microfabricated oxygen sensors that used die-level drop cast Nafion membranes that were not annealed [21,23,28].…”

Section: Discussionmentioning

confidence: 94%

“…This enables the device to be fully solid-state. Several other designs of microfabricated electrochemical oxygen sensors have previously been described [18][19][20][21][22][23][24][25][26][27][28][29][30][31], highlighting the broad interest in this technology. However, to date no design has been reported that is not only amenable to wafer-level CMOS post-processing, and integrated with a stable on-chip RE and membrane, but also successfully validated in an implantable application.…”

Section: Introductionmentioning

confidence: 99%

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Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor

Marland¹,

Gray²,

Dunare³

et al. 2020

Preprint

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Hypoxia commonly occurs within tumours and is a major cause of radiotherapy resistance. Clinical outcomes could be improved by locating and selectively increasing the dose delivered to hypoxic regions. Here we describe a miniature implantable sensor for real-time monitoring of tissue oxygenation that could enable this novel treatment approach to be implemented. The sensor uses a solid-state electrochemical cell that was microfabricated at wafer level on a silicon substrate, and includes an integrated reference electrode and electrolyte membrane. It gave a linear response to oxygen concentration, and was unaffected by sterilisation and irradiation, but showed susceptibility to biofouling. Oxygen selectivity was also evaluated against various clinically relevant electroactive compounds. We investigated its robustness and functionality under realistic clinical conditions using a sheep model of lung cancer. The sensor remained functional following CT-guided tumour implantation, and was sufficiently sensitive to track acute changes in oxygenation within tumour tissue.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor

Marland¹,

Gray²,

Dunare³

et al. 2020

Preprint

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“…Recent research reviews have shown that environmental sensors are mostly resistive or capacitive [17] and conventional healthcare sensors are typically measured based on voltage or current [18]. Therefore, this paper proposes a heterogeneous multi-sensor interface that is implemented with two chips: an environmental sensor readout integrated circuit (E-ROIC) for resistive and capacitive sensor types and a healthcare sensor readout integrated circuit (H-ROIC) for voltage and current sensor inputs.…”

Section: Multi-sensor System Architecturementioning

confidence: 99%

A Multisensor Mobile Interface for Industrial Environment and Healthcare Monitoring

Choi

Kim²,

Choi³

et al. 2017

IEEE Trans. Ind. Electron.

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This work presents a reconfigurable multi-sensor mobile interface architecture that is applicable to heterogeneous sensor applications and also easy to generate new types of combined services. The multi-sensor interface attributes compactness and flexibility to reconfigurable readout integrated circuits (ROICs) and migration of signal processing and computation burdens from a sensor tag to a smartphone. Two reconfigurable ROICs which were designed and fabricated in a 0.18-m CMOS process generate raw digital data from environmental and healthcare sensors. Their detected raw data are wirelessly sent to the smartphone where real-time calibration and post-processing are performed optimally for each sensor. In an application to industrial systems, an in-vehicle system prototype supporting combined monitoring services of air-quality and healthcare was integrated into a steering wheel cover and experimentally verified to provide real-time measurement of three environmental sensor signals and two healthcare physiological signals with the results displayed on a smartphone. Index Terms-Multi-sensorinterface, reconfigurable readout circuits, in-vehicle monitoring, healthcare, air quality, mobile system, heterogeneous systems. in 2011, respectively. Since then, he has been with uMEDIX Inc., Seoul, Korea, where he is currently the Senior Research Engineer of Technology and R&D. Yun Young Choi received the M.E. degree in electrical engineering from the Chonnam University, Chonnam, Korea, in 2002, respectively. In 2000, he joined Hynix Inc., where he was involved in developing the Bluetooth Transceivers for GSM cellular phone applications. In 2006, he joined Samsung Electronics, where he developed the world-first LTE/WCDMA+GSM Transceivers for LTE phone applications. Since 2010, he has been with uMEDIX Inc., Seoul, Korea, where he is currently the Chief Technology Office of Technology and R&D, participating in developing biomedical devices and systems including bio-potential readout integrated circuits.

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“…This is a polymer with ionic properties that contains hydrated channels capable of conducting protons [1]. It has been reported as a suitable electrolyte membrane in electrochemical sensors that detect dissolved oxygen [2]- [4], however little has been reported about microfabrication of Nafion membranes. In order to explore this issue quantitatively, we report the use of test structures to characterize and optimize the design and patterning of Nafion.…”

Section: Introductionmentioning

confidence: 99%

Test structures for optimizing polymer electrolyte performance in a microfabricated electrochemical oxygen sensor

Marland

Dunare

Tsiamis

et al. 2017

2017 International Conference of Microelectronic Test Structures (ICMTS)

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A Monolithically Integrated Pressure/Oxygen/Temperature Sensing SoC for Multimodality Intracranial Neuromonitoring

Cited by 31 publications

References 23 publications

Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor

Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor

A Multisensor Mobile Interface for Industrial Environment and Healthcare Monitoring

Test structures for optimizing polymer electrolyte performance in a microfabricated electrochemical oxygen sensor

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