A molecularly imprinted polymer based on MOF and deep eutectic solvent for selective recognition and adsorption of bovine hemoglobin

Han, Song‐De; Yao, Aixin; Ding, Yuxin; Leng, Qiuxue; Fu, Teng

doi:10.1007/s00216-021-03520-3

Cited by 24 publications

(1 citation statement)

References 31 publications

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“…Zhang et al 37 prepared MOFs@graphene hybrid aerogels for selective enrichment of ribonuclease A (RNase A) by a facile templatefree "sol-cryo" method for the first time. Han et al 38 prepared a novel imprinted polymer based on MOFs using bovine hemoglobin (BHb) as a template molecule and a deep eutectic solvent as a functional monomer. The material exhibited a maximum adsorption capacity of 151.28 mg/g for BHb with good selectivity, and it can reach adsorption equilibrium rapidly, which provides a new approach for the preparation and study of biomolecule-imprinted polymers.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Metal Ion–BSA Chelation-Targeted Surface-Imprinted Particles for Protein Separation

Wang

Lyu

Yang

et al. 2023

Ind. Eng. Chem. Res.

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The development of high-performance protein-imprinted materials for adsorption and separation to obtain high-purity, high-quality biomolecules is still one of the most important techniques to promote the rapid development of the protein drug industry. In this paper, a novel highly specific bovine serum albumin (BSA) cobalt–molybdenum double-hydroxides surface-imprinted composite particles (Co–Mo LDHs@MIPs) were constructed by the surface imprinting technique combined with metal chelation. ZIF-67 was etched by molybdate ions to obtain unique MOF-derived bimetallic hydroxide particles (Co–Mo LDHs), which were used as the carrier. The rough outer surface and bimetallic ion coordination of Co–Mo LDHs enable anchoring more template proteins. The adsorption capacity of Co–Mo LDHs@MIPs was up to 423.37 mg/g for BSA in 60 min with an imprinting factor of 2.65. In addition, Co–Mo LDHs@MIPs can selectively recognize and separate BSA from mixed proteins and fetal bovine serum and exhibit high reusability stability.

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Section: Introductionmentioning

confidence: 99%