“…Regardless of whether the analytes are generated by the biological sample itself (VOCs and metabolites) or added into the biological sample leading to bioaccumulation, they can be extracted effectively by using a suitable SPME device. These SPME devices coupled with highly sensitive instruments have great potential for the analysis of human biofluids, − including urine, serum, and saliva, which are also practical for the analysis of hair samples, exhaled breath, and body odor . Since these human samples are gases, solids, and liquids with complex matrixes, more diverse and modified extraction devices have been employed for efficient sample cleanup and analyte concentration.…”