A molecularly imprinted electrochemical sensors based on bamboo-like carbon nanotubes loaded with nickel nanoclusters for highly selective detection of cortisol

Duan, Dingding; Lü, Huan; Li, Li; Ding, Yaping; Ma, Guohong

doi:10.1016/j.microc.2022.107231

Cited by 29 publications

(17 citation statements)

References 33 publications

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“…The polymerization process begins with the preparation of a solution containing monomers, molecular templates, porogenic solvents, and cross-linkers. Pyrrole was the most frequently used monomer for the MIP cortisol production process [ 70 , 71 , 72 , 73 ], followed by o-phenylenediamine [ 4 , 74 ]. Pyrrole is considered an appropriate monomer because it is conductive, can be synthesized in a liquid medium, and is chemically stable, especially at neutral pH.…”

Section: Molecularly Imprinted Polymermentioning

confidence: 99%

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Molecularly Imprinted Polymer-Based Sensor for Electrochemical Detection of Cortisol

2022

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As a steroid hormone, cortisol has a close relationship with the stress response, and therefore, can be used as a biomarker for early detection of stress. An electrochemical immunosensor is one of the most widely used methods to detect cortisol, with antibodies as its bioreceptor. Apart from conventional laboratory-based methods, the trend for cortisol detection has seemed to be exploiting antibodies and aptamers. Both can provide satisfactory performance with high selectivity and sensitivity, but they still face issues with their short shelf life. Molecularly imprinted polymers (MIPs) have been widely used to detect macro- and micro-molecules by forming artificial antibodies as bioreceptors. MIPs are an alternative to natural antibodies, which despite demonstrating high selectivity and a low degree of cross-reactivity, often also show a high sensitivity to the environment, leading to their denaturation. MIPs can be prepared with convenient and relatively affordable fabrication processes. They also have high durability in ambient conditions, a long shelf life, and the ability to detect cortisol molecules at a concentration as low as 2 ag/mL. By collecting data from the past five years, this review summarizes the antibody and aptamer-based amperometric sensors as well as the latest developments exploiting MIPs rather than antibodies. Lastly, factors that can improve MIPs performance and are expected to be developed in the future are also explained.

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Section: Molecularly Imprinted Polymermentioning

confidence: 99%

“…By adjusting potential ranges, scan rates, and the number of scans in CV parameters, any increase or decrease in the voltammogram of each scan can be observed. Its layer formation behavior can also be analyzed through this adjustment [ 74 ].…”

Section: Mip Optimization and Electrochemical Detection Of Cortisolmentioning

confidence: 99%

Molecularly Imprinted Polymer-Based Sensor for Electrochemical Detection of Cortisol

2022

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“…Several reports have examined the use of modified MIP electrode sensors. − This study applied a polymer-containing N -methacryloyl-( l )-histidine methyl ester (MAH) to create a PGE surface that could initiate electron transfer and enhance sensitivity for cortisol detection. The addition of AgNPs was also evaluated to improve sensitivity in the MIP@AgNPs system further.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Detection of Cortisol by Silver Nanoparticle-Modified Molecularly Imprinted Polymer-Coated Pencil Graphite Electrodes

et al. 2023

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The sensitive cortisol detection by an electrochemical sensor based on silver nanoparticle-doped molecularly imprinted polymer was successfully improved. This study describes the method development for cortisol detection in both aqueous solution and biological samples using molecularly imprinted poly(hydroxyethyl methacrylate-N-methacryloyl-(l)-histidine methyl ester)-coated pencil graphite electrodes modified with silver nanoparticles (AgNPs) by differential pulse voltammetry (DPV). The cortisol-imprinted pencil graphite electrode (PGE) has a large surface area because of doped AgNPs with enhanced electroactivity. The prepared molecularly imprinted polymer was characterized by scanning electron microscopy. The DPV response of the synthesized electrode with outstanding electrical conductivity was clarified. Cortisol-imprinted polymer-coated PGEs (MIP), cortisol-imprinted polymer-coated PGEs with AgNPs (MIP@AgNPs), and nonimprinted polymer-coated PGEs with AgNPs (NIP@AgNPs) were evaluated for sensitive and selective detection of cortisol in aqueous solution. Five different cortisol concentrations (0.395, 0.791, 1.32, 2.64, and 3.96 nM) were applied to the MIP@AgNPs, and signal responses were detected by the DPV with a regression coefficient (R 2) value of 0.9951. The modified electrode showed good electrocatalytic activity toward cortisol for the linear concentration range from 0.395 to 3.96 nM, and a low limit of detection was recorded as 0.214 nM. The results indicate that the MIP@AgNPs sensor has great potential for sensitive and selective cortisol determination in biological samples.

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“…12 Unlike biological receptors such as antibodies, antigens, and enzymes, MIPs have a number of potential benefits, including increased stability, durability, affordability, and ease of manufacture. 13,14 Molecular imprinting is a technique for developing specific binding affinity in synthetic polymers using molecular templates and is a potential technology for developing synthetic receptors that have the molecular recognition properties of biological systems. 15,16 Finally, nanoscale imprinted substances are likely to have a number of significant benefits compared to usual imprinted substances, including quicker template removal, better binding capacity, rapid binding kinetics, and relatively easy installation onto nanodevice surfaces, among others.…”

Section: Introductionmentioning

confidence: 99%

“…Unlike biological receptors such as antibodies, antigens, and enzymes, MIPs have a number of potential benefits, including increased stability, durability, affordability, and ease of manufacture. 13,14 Molecular imprinting is a technique for developing specific binding affinity in synthetic polymers using molecular templates and is a potential technology for developing synthetic receptors that have the molecular recognition properties of biological systems. 15,16…”

Section: Introductionmentioning

confidence: 99%

Fabrication of an imprinted polymer based graphene oxide composite for label-free electrochemical sensing of Sus DNA

et al. 2022

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A molecularly imprinted electrochemical sensors based on bamboo-like carbon nanotubes loaded with nickel nanoclusters for highly selective detection of cortisol

Cited by 29 publications

References 33 publications

Molecularly Imprinted Polymer-Based Sensor for Electrochemical Detection of Cortisol

Molecularly Imprinted Polymer-Based Sensor for Electrochemical Detection of Cortisol

Electrochemical Detection of Cortisol by Silver Nanoparticle-Modified Molecularly Imprinted Polymer-Coated Pencil Graphite Electrodes

Fabrication of an imprinted polymer based graphene oxide composite for label-free electrochemical sensing of Sus DNA

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