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Molecularly imprinted particles embedded composite cryogel discs specific for a-cypermethrin and bcypermethrin were prepared. Two different types of imprinted particles were embedded into cryogel to prepare composite cryogels specific for two isomers of cypermethrin simultaneously. Adsorption studies revealed that MIP is extremely selective for a-cypermethrin and b-cypermethrin with outstanding adsorption capacity. A sensitive analytical method comprising MISPE coupled with GC-MS has been developed to quantify trace levels of a-cypermethrin and b-cypermethrin in real water matrices. The polymer showed fast kinetics and follows a pseudo-second-order kinetic model very well (R 2 ¼ 0.9999).It shows excellent capacity towards a-cypermethrin and b-cypermethrin with a higher total number of binding sites (N t ¼ 96 mmol g À1 for a-cypermethrin and 95 mmol g À1 for b-cypermethrin). The MIP showed selectivity over the homologues of a-cypermethrin and b-cypermethrin with imprinting factor (IF) 11.2, 10.0, 1.04 and 1.20 for a-cypermethrin, b-cypermethrin, deltamethrin and permethrin, respectively. The developed MISPE method followed by GC-MS enhanced the sensitivity and selectivity of the assay. This method was successfully applied to samples of lake water for the determination of a-cypermethrin and b-cypermethrin simultaneously. Moreover, the synthesized MIP can be easily regenerated and repeatedly used without loss of efficiency.

Controlled drug delivery system is a technique which has considerable recent potential in the fields of pharmacy and medicine. Mitomycin C is commonly used drug in the treatment of superficial bladder and breast cancers. In the present study, mitomycin C-imprinted magnetic poly(hydroxyethyl methacrylate)-based nanoparticles (MIMNs) were prepared using surfactant free emulsion polymerization for controlled delivery of mitomycin C. The MIMNs were characterized by fourier transform infrared spectroscopy, scanning electron microscopy, atomic force microscopy, electron spin resonance, and elemental analysis. The average particle diameter of MIMNs was about 200 nm.

Implementation of Brij-35, a nonionic surfactant, as a mobile phase for separation of positional isomers is investigated. Chromolith C-18 SpeedROD is used as a stationary phase. The effect of surfactant and organic modifier (propanol) concentration on the separation of some selected isomers is studied and evaluated in terms of linear solvation energy relationship (LSER). Shape selectivity is assessed by α value of sorbic and benzoic acid, which is found to be 1.339 by using mobile phase composed of 0.5% aqueous solutions of Brij-35 and propanol in 9 : 1. Isomers of parabens, nitroanilines, nitrophenols, and quinolinols are successfully separated using mobile phases composed of various percentages of surfactant and propanol. System constants for nonionic MLC using LSER analysis show that hydrogen bond basicity and dipolarity may be major contributors to selectivity, while excess molar refraction helps fine-tuning the separation which also imparts unique selectivity to nonionic surfactants as compared to ionic ones.

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