A molecular insight of inflammatory cascades in rheumatoid arthritis and anti-arthritic potential of phytoconstituents

Patidar, Vaibhav; Shah, Shruti; Kumar, Rahul; Singh, Pankaj Kumar; Singh, Shashi Bala; Khatri, Dharmendra Kumar

doi:10.1007/s11033-021-06986-7

Cited by 5 publications

(9 citation statements)

References 132 publications

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Section: Introductionmentioning

confidence: 99%

“…Rheumatoid arthritis (RA) is an autoimmune disease characterized by pannus formation involving activated fibroblast-like synoviocytes (FLS) [1,2]. Pannus, a thick and swollen synovial membrane, consists of myofibroblast, fibroblast and inflammatory cells [1]. Intercellular communication between FLS and immunocompetent cells through inflammatory cytokines is important for pannus formation [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…Pannus, a thick and swollen synovial membrane, consists of myofibroblast, fibroblast and inflammatory cells [1]. Intercellular communication between FLS and immunocompetent cells through inflammatory cytokines is important for pannus formation [1][2][3]. Within the joints of RA, synovial cells proliferate to form pannus, and immunocompetent cells enter the synovial tissue via neovascularization, followed by immune activation, which leads to pain, arthritis, and joint swelling [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…Intercellular communication between FLS and immunocompetent cells through inflammatory cytokines is important for pannus formation [1][2][3]. Within the joints of RA, synovial cells proliferate to form pannus, and immunocompetent cells enter the synovial tissue via neovascularization, followed by immune activation, which leads to pain, arthritis, and joint swelling [1,2]. Pannus in the vicinity of the bone also causes joint destruction by secreting large amounts of matrix metalloproteinase (MMP) [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…Within the joints of RA, synovial cells proliferate to form pannus, and immunocompetent cells enter the synovial tissue via neovascularization, followed by immune activation, which leads to pain, arthritis, and joint swelling [1,2]. Pannus in the vicinity of the bone also causes joint destruction by secreting large amounts of matrix metalloproteinase (MMP) [1,2]. Thus, activated FLS, which play a central role in the pannus, contribute to the pathogenesis of RA.…”

Section: Introductionmentioning

confidence: 99%

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Tocopheryl Phosphate Inhibits Rheumatoid Arthritis-Related Gene Expression In Vitro and Ameliorates Arthritic Symptoms in Mice

et al. 2022

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Anti-rheumatoid arthritis (RA) effects of α-tocopherol (α-T) have been shown in human patients in a double-blind trial. However, the effects of α-T and its derivatives on fibroblast-like synoviocytes (FLS) during the pathogenesis of RA remain unclear. In the present study, we compared the expression levels of genes related to RA progression in FLS treated with α-T, succinic ester of α-T (TS), and phosphate ester of α-T (TP), as determined via RT-PCR. The mRNA levels of interleukin (IL)-6, tumor necrosis factor-α (TNF-α), matrix metalloproteinase (MMP)-3, and MMP-13 were reduced by treatment with TP without cytotoxicity, while α-T and TS did not show such effects. Furthermore, intraperitoneal injection of TP ameliorated the edema of the foot and joint and improved the arthritis score in laminarin-induced RA model mice. Therefore, TP exerted anti-RA effects through by inhibiting RA-related gene expression.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Tocopheryl Phosphate Inhibits Rheumatoid Arthritis-Related Gene Expression In Vitro and Ameliorates Arthritic Symptoms in Mice

et al. 2022

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Exploring the mechanism of Celastrol in the treatment of rheumatoid arthritis based on systems pharmacology and multi-omics

Zeng,

Yu,

Yang

et al. 2024

Sci Rep

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To explore the molecular network mechanism of Celastrol in the treatment of rheumatoid arthritis (RA) based on a novel strategy (integrated systems pharmacology, proteomics, transcriptomics and single-cell transcriptomics). Firstly, the potential targets of Celastrol and RA genes were predicted through the database, and the Celastrol-RA targets were obtained by taking the intersection. Then, transcriptomic data and proteomic data of Celastrol treatment of RA were collected. Subsequently, Celastrol-RA targets, differentially expressed genes, and differentially expressed proteins were imported into Metascape for enrichment analysis, and related networks were constructed. Finally, the core targets of Celastrol-RA targets, differentially expressed genes, and differentially expressed proteins were mapped to synoviocytes of RA mice to find potential cell populations for Celastrol therapy. A total of 195 Celastrol-RA targets, 2068 differential genes, 294 differential proteins were obtained. The results of enrichment analysis showed that these targets, genes and proteins were mainly related to extracellular matrix organization, TGF-β signaling pathway, etc. The results of single cell sequencing showed that the main clusters of these targets, genes, and proteins could be mapped to RA synovial cells. For example, Mmp9 was mainly distributed in Hematopoietic cells, especially in Ptprn+fibroblast. The results of molecular docking also suggested that Celastrol could stably combine with molecules predicted by network pharmacology. In conclusion, this study used systems pharmacology, transcriptomics, proteomics, single-cell transcriptomics to reveal that Celastrol may regulate the PI3K/AKT signaling pathway by regulating key targets such as TNF and IL6, and then play an immune regulatory role.

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Does Dietary Polyunsaturated Fatty Acid Intake Associate With Bone Mineral Density and Limb Structural Changes in Early Rheumatoid Arthritis?

Valner

Müller

Kull³

et al. 2023

Nutr Metab Insights

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Background: Rheumatoid arthritis (RA) is an inflammatory disease that can result in bone erosion, lean mass lowering, and increase of fat mass without changes in body weight. The dietary consumption of polyunsaturated fatty acids (PUFAs) has been assessed in many studies due to their potential anti-inflammatory effect. Aim: The aim of this research was to identify if dietary intake of PUFAs associates with bone mineral density (BMD) and limb structural changes in early rheumatoid arthritis (ERA) compared to a population-based control group. The study was conducted because previous results have been insufficient. Methods: The study group consisted of 83 ERA patients and 321 control subjects. A dual-energy X-Ray absorptiometry (DXA) machine was used to measure hip, lumbar spine, and radius BMD, as well as arm and leg fat, lean, and bone mass. Dietary habits and inflammatory markers were assessed to evaluate the effects to BMD and limb structural changes. Results: In ERA subjects, higher dietary consumption of PUFAs was associated with a decrease in arm fat mass (b −28.17, P = .02) and possibly with higher lumbar BMD (b 0.008, P = .058). Limb bone and lean mass changes were not associated with dietary intake of PUFAs. Conclusion: Balanced nutrition is essential. Consuming PUFAs could be beneficial in ERA preventing structural changes to hands, but additional research is needed.

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A molecular insight of inflammatory cascades in rheumatoid arthritis and anti-arthritic potential of phytoconstituents

Cited by 5 publications

References 132 publications

Tocopheryl Phosphate Inhibits Rheumatoid Arthritis-Related Gene Expression In Vitro and Ameliorates Arthritic Symptoms in Mice

Tocopheryl Phosphate Inhibits Rheumatoid Arthritis-Related Gene Expression In Vitro and Ameliorates Arthritic Symptoms in Mice

Exploring the mechanism of Celastrol in the treatment of rheumatoid arthritis based on systems pharmacology and multi-omics

Does Dietary Polyunsaturated Fatty Acid Intake Associate With Bone Mineral Density and Limb Structural Changes in Early Rheumatoid Arthritis?

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