Tocopheryl Phosphate Inhibits Rheumatoid Arthritis-Related Gene Expression In Vitro and Ameliorates Arthritic Symptoms in Mice

Hama, Susumu; Kirimura, Naoko; Obara, Aki; Takatsu, Hirokatsu; Kogure, Kentaro

doi:10.3390/molecules27041425

Cited by 2 publications

(1 citation statement)

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“…According to some authors, α-TP is a potentially stronger anti-proliferative agent than α-T [16,17]. Due to its potent biological activity, α-TP is still the subject of numerous investigations [18][19][20]. α-TS is unstable under physiological conditions because of cellular esterases' activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of α-Tocopherol Derivatives as Potential Anticancer Agents

et al. 2023

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α-Tocopheryl succinate (α-TS) and α-tocopheryloxyacetic acid (α-TEA) are potent inducers of apoptosis in cancer cells and efficient suppressors of tumors in experimental model cancer cell lines. They exhibit selective cytotoxicity against tumor cells and very limited or no toxicity toward nonmalignant cells. In the present work, a series of new α-tocopherol derivatives were synthesized as analogs of α-TS and α-TEA. The cytotoxic activity of obtained compounds was tested using three human cancer cell lines, including chronic lymphoblastic leukemia (CEM), breast adenocarcinoma (MCF7), cervical adenocarcinoma (HeLa), and normal human fibroblasts (BJ). The introduction of an alkyl substituent into the ether-linked acetic acid moiety in α-TEA increased anticancer activity. α-Tocopheryloxy-2-methylpropanoic acid with two additional geminal methyl groups was more active against CEM cells compared to α-TEA and non-toxic to normal cells. In order to acquire a deeper understanding of the biological activity of synthesized compounds, a molecular docking study was also conducted. Our research confirmed that vitamin E derivatives are interesting and valuable compounds in terms of their potential therapeutic use as anticancer agents.

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