A molecular imprinted polymer on the surface of superparamagnetic Fe₃O₄–graphene oxide (MIP@Fe₃O₄@GO) for simultaneous recognition and enrichment of evodiamine and rutaecarpine in Evodiae fructus

Abstract

A composite material (MIP@Fe 3 O 4 @GO) based on molecular imprinted polymer (MIP), superparamagnetic Fe 3 O 4 particles and graphene oxide (GO) was prepared by the chemical coprecipitation method, and used to simultaneously separate and enrich two alkaloids (evodiamine and rutaecarpine) in the extract of Evodiae fructus. The as-prepared MIP@Fe 3 O 4 @GO was characterized by Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), and vibrating sample magnetometer (VSM). The adsorption kinetics, isotherms, competitive adsorption, and reusability of MIP@Fe 3 O 4 @GO were also investigated. The results revealed that MIP@Fe 3 O 4 @GO was sensitive to the magnetic field and could be easily separated using an external magnet; MIP@Fe 3 O 4 @GO showed good recognition selectivity, as well as simultaneous enrichment and separation abilities for evodiamine and rutaecarpine in the extract of E. fructus with satisfactory recoveries.

A Novel and High-Effective Biosynthesis Pathway of Hesperetin-7-O-Glucoside Based on the Construction of Immobilized Rhamnosidase Reaction Platform

“…In the spectrum of GO, the peak appeared at 1729 cm −1 attributed to the stretching band of C = O in carboxylic acid or carbonyl moieties, the rest peaks of 3604, 1399, 1220 cm −1 could be corresponding to the stretching vibration of O-H, C-O, O-H groups (Kassaee et al, 2011). The Fe 3 O 4 @GO spectrum differed in that the peak of O-H at 3736 cm −1 was obviously weaken, and the Fe-O stretching peak approximately at 480 cm −1 could be seen, which confirmed Fe 3 O 4 particles successfully anchored onto the GO (Fan et al, 2017). In addition, the Fe 3 O 4 @GO curve was a little blue-shift relative to the GO curve, the reason may be that the large Fe 3 O 4 particle loaded on the surface of GO, leading to a change in the charge density (Peng-Fei et al, 2000).…”

Synthesis of Molecularly Imprinted Polymer on Magnetic Core-Shell Silica Nanoparticles for Recognition of Congo Red

“…The parameter m is the heterogeneity index, with values from 0 to 1, indicating homogeneity of the sites. In fact, m becomes closer to 1 as heterogeneity decreases, a homogeneous system has m=1 [27].…”

Molecularly Imprinted Polymers for Dispersive (Micro)Solid Phase Extraction: A Review

“…Regarding magnetic nanosheet-supported MIPs (Table 2), the GO@Fe 3 O 4 surface is usually functionalized by grafting with acrylic acid as shown in Figure 4 [33,151], which ensure the presence of vinyl groups for further polymerization. Acrylic acid was also used for surface modification of chitosan based GO@Fe 3 O 4 composites [152].…”

“…However, prepared GO@Fe 3 O 4 nanoparticles [155,156], as well as 3D magnetic GO-CNT composites [35], were also directly used for MIP synthesis without functionalization. [33,151], which ensure the presence of vinyl groups for further polymerization. Acrylic acid was also used for surface modification of chitosan based GO@Fe3O4 composites [152].…”