A molecular docking study repurposes FDA approved iron oxide nanoparticles to treat and control COVID-19 infection

Abo‐zeid, Yasmin; Ismail, Nasser S. M.; McLean, Gary R.; Hamdy, Nadia M.

doi:10.1016/j.ejps.2020.105465

Cited by 187 publications

(135 citation statements)

References 39 publications

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“…The safety of the nanotechnological products used in medicine is monitored and approved by the FDA [34,148]. There are already several cases of FDA-approved NP-based antivirals against different viruses, including influenza [145,149,150].…”

Section: Resultsmentioning

confidence: 99%

Anti-Influenza Strategies Based on Nanoparticle Applications

2020

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Influenza virus has the potential for being one of the deadliest viruses, as we know from the pandemic’s history. The influenza virus, with a constantly mutating genome, is becoming resistant to existing antiviral drugs and vaccines. For that reason, there is an urgent need for developing new therapeutics and therapies. Despite the fact that a new generation of universal vaccines or anti-influenza drugs are being developed, the perfect remedy has still not been found. In this review, various strategies for using nanoparticles (NPs) to defeat influenza virus infections are presented. Several categories of NP applications are highlighted: NPs as immuno-inducing vaccines, NPs used in gene silencing approaches, bare NPs influencing influenza virus life cycle and the use of NPs for drug delivery. This rapidly growing field of anti-influenza methods based on nanotechnology is very promising. Although profound research must be conducted to fully understand and control the potential side effects of the new generation of antivirals, the presented and discussed studies show that nanotechnology methods can effectively induce the immune responses or inhibit influenza virus activity both in vitro and in vivo. Moreover, with its variety of modification possibilities, nanotechnology has great potential for applications and may be helpful not only in anti-influenza but also in the general antiviral approaches.

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Section: Resultsmentioning

confidence: 99%

Anti-Influenza Strategies Based on Nanoparticle Applications

2020

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“…The copyright holder for this this version posted December 11, 2020. ; https://doi.org/10.1101/2020.12.10.20247130 doi: medRxiv preprint studies revealed that iron oxide nanoparticles interact efficiently with the SARS-CoV-2 spike binding proteins [22].…”

Section: Resultsmentioning

confidence: 99%

Airborne magnetic nanoparticles: environmental risk factors for the transmission of SARS-CoV-2

Martínez-Boubeta¹,

Simeonidis

2020

Preprint

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ObjectivesTo examine the impact of concentrations of ambient fine particulate matter (PM2.5) air pollution on the incidence of COVID-19.MethodsPublicly available data of COVID-19 deaths in March/October 2020 were compared with concentrations of PM2.5 measured in previous years at urban and suburban areas in Thessaloniki. Similar publicly available data of PM2.5 concentrations from Tehran were gathered for comparison. Cross-correlation and Granger causality analysis were performed in order to assess linkage.ResultsOn the one hand, the mean PM2.5 concentrations in Thessaloniki were significantly higher in the winter, however the magnetic fraction of particulate matter in the autumn is twice its annual average, suggesting that traffic-related emissions alone may not explain the entire variability of PM2.5. On the other hand, it is implied that changes in coronavirus-related deaths follow changes in airborne magnetite, with the correlation between the two data sets being maximized at the lag time of one-month. Further insight is provided by the monthly pattern of PM2.5 mass concentrations in Tehran. We find that air pollution Granger causes COVID-19 deaths (p<0.05).ConclusionsA significant association has been found between PM2.5 values and the impact of the COVID-19 pandemic on a bunch of regions. Reported links between pollution levels, climate conditions and other factors affecting vulnerability to COVID-19 may instead reflect inhalation exposure to magnetic nanoparticles. A hypothesis has been set that ubiquitous airborne magnetite pollution, together with certain climatic conditions, may promote a longer permanence of the viral particles in the air, thus favoring transmission.Key messagesWhat is already known about this subject?▸▸Due to their small dimensions, airborne particles are able to penetrate through inhalation into many human organs, from the lungs to the cardiovascular system and the brain, which can threaten our health. Research has shown that air pollution is an important cofactor increasing the risk of mortality from coronaviruses.What are the new findings?▸▸Evidence exists that the magnetic fraction of PM has modulated the transmission of SARS-CoV-2 in Thessaloniki, and potentially in any other region in the world.How might this impact on policy or clinical practice in the foreseeable future?▸▸Policymakers should take care not to overestimate the effect of social distancing interventions and should consider the impact of air pollution in current or future epidemic waves.

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“…The study reported that both the iron oxide nanoparticles interacted with S-RBD. It was also revealed that a more stable compound was formed by Fe 3 O 4 with S-RBD [ 23 ].…”

Section: Metal Nanoparticles Affect Sars-cov-2 Targetsmentioning

confidence: 99%