A modulating effect of epigallocatechin gallate (EGCG), a tea catechin, on the bladder of rats exposed to water avoidance stress

Abstract

EGCG given at 1 mg/kg I.P to rats has a significant protective effect against bladder degenerative changes following WAS.

Evaluation of oxidative stress status and antioxidant capacity in patients with painful bladder syndrome/interstitial cystitis: preliminary results of a randomised study

“…Our study is promising for further studies, which aim to evaluate several other oxidative stress parameters together with the present markers of this study, thus determining optimal diagnostic markers of the disease. Additionally, our study supports the results of previous experimental studies, emphasizing oxidative damage in etiology of PBS/IC [25,[35][36][37]. Therefore, this might lighten further studies, for the choice of the most effective therapy of the disease.…”

Repeated variate stress in male rats induces increased voiding frequency, somatic sensitivity, and urinary bladder nerve growth factor expression

“…These studies demonstrate increased voiding frequency, histamine, MPO, NGF, and CXCL12 bladder content and somatic sensitivity after RVS suggesting an inflammatory component to stress-induced changes in bladder function and somatic sensitivity. micturition; stress; nerve growth factor; ELISA; somatic sensitivity STRESS CONTRIBUTES to symptom exacerbation in many disease states, including functional disorders of the urinary bladder such as overactive bladder (OAB) and interstitial cystitis (IC)/ bladder pain syndrome (BPS) (3,38,58,72). Urinary frequency is a common symptom among patients with OAB or IC/BPS, although the end result of frequent voiding may differ [reduce incontinence episodes (OAB) vs. reduce pain with bladder filling (IC/BPS)].…”

The role of C‐fibers in the development of chronic psychological stress induced enhanced bladder sensations and nociceptive responses: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome (MAPP) research network study

“…Understanding the mechanism by which stress leads to bladder hyperalgesia in susceptible individuals will provide new treatment opportunities to IC/PBS and other such lower urinary tract conditions were stress have been shown to increased symptom duration and exacerbations. Chronic WAS‐induced bladder inflammation has been validated by experimental findings from several studies, including bladder inflammatory cells infiltration, increased vascular congestion, and upregulated inflammation markers and may serve as a possible mechanism . Bladder inflammation can modulate properties of sensory afferents and activate bladder afferent nociceptors .…”