A Modified Tc-99m-Phytate Colloid for Liver–Spleen Imaging

Davis, Michael A.; Kaplan, Melvin H.; Ahnberg, Donald S.; Cole, Clyde N.

doi:10.1016/b978-0-08-021344-6.50018-5

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…99m Tc-phytate, which was initially described as a radiopharmaceutical for reticuloendothelial system scintigraphy in 1977, forms colloid upon reaction with ionized calcium [13]. 99m Tc-phytate uptake occurs predominantly in the liver, rather than the spleen, after intravenous injection, which results in the formation of particles with a small diameter in the blood.…”

Section: Discussionmentioning

confidence: 99%

Sentinel lymph node identification with radiopharmaceuticals in patients with breast cancer: a comparison of 99mTc-tin colloid and 99mTc-phytate efficiency

Seok

Choi

Chong

et al. 2010

Breast Cancer Res Treat

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Sentinel lymph node biopsy with lymphoscintigraphy has become the standard method for the detection of axillary lymph node metastasis in breast cancer patients. However, there is no standardized radiopharmaceutical. For the detection of axillary lymph node metastasis by lymphoscintigraphy and sentinel node biopsy in patients with breast cancer, we compared the results between subareolar injection of (99m)Tc-tin colloid and injection of (99m)Tc-phytate. This study included 516 breast cancer patients who underwent surgery between 2001 and 2010. Among the 516 patients, (99m)Tc-tin colloid (37-185 MBq) was administered to 412 patients by subareolar injection, and (99m)Tc-phytate (37-185 MBq) was injected in 104 patients. Lymphoscintigraphy was performed with the patients in the supine position, and sentinel node identification was performed by hand-held gamma probe during surgery. Among 412 patients with (99m)Tc-tin colloid, the sentinel node was identified by lymphoscintigraphy in 364 cases (88.3%) and by a gamma probe in 369 cases (89.6%). Among 104 patients with (99m)Tc-phytate, 101 cases (97.1%) were identified by lymphoscintigraphy and 101 cases (97.1%) were identified by a gamma probe. The identification rates by lymphoscintigraphy and gamma probe were superior with (99m)Tc-phytate, as compared with (99m)Tc-tin colloid, with a statistically significant difference (P < 0.05 for both methods). (99m)Tc-phytate is a better choice than (99m)Tc-tin colloid for identification of the sentinel node in breast cancer patients.

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Section: Discussionmentioning

confidence: 99%

Sentinel lymph node identification with radiopharmaceuticals in patients with breast cancer: a comparison of 99mTc-tin colloid and 99mTc-phytate efficiency

Seok

Choi

Chong

et al. 2010

Breast Cancer Res Treat

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“…Phytate colloid is now available as an instant labeling kit in Japan. The simple addition of normal saline containing 99m Tc pertechnetate to this labeling kit yields 99m Tc‐phytate colloids with diameters between 100 and 200 nm 29 ; the size of colloidal particles grows further upon reaction with ionized calcium in vivo, 30 and these enlarged colloidal particles are preferentially phagocytosed by macrophages. Therefore, 99m Tc‐labeled phytate colloids are the tracers of choice for hepatosplenic scintigraphy.…”

Section: Discussionmentioning

confidence: 99%

Novel Indocyanine Green–Phytate Colloid Technique for Sentinel Node Detection in Head and Neck: Mouse Study

Araki

Mizokami

Tomifuji

et al. 2014

Otolaryngol.--head neck surg.

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“…Technetium-99m-Phytate (" m Tccomplex of inositolhexaphosphoric acid) is a well-known and widely used radiopharmaceutical for liver imaging. Since 1973, when it was proposed (11) as a useful agent for imaging of the reticulo-endothelial system, it has been widely used in a way similar to " m Tc-S-colloid (4,10) and " m Tc-Sncolloid (2,7). A specific feature of " m Tc-phytate is that it is introduced in the human organism as a solution and, by interaction with calcium ions from the blood, is transformed into a microcolloid in vivo and is actively deposited in the reticuloendothelial system, of which the hepatic Kupffer cell is the major component (2).…”

Section: Introductionmentioning

confidence: 99%

Studies of the Chemical and Biological Properties of the Liver-Imaging Agent 99mTc-Phytate

Vanlić-Razumenić¹,

Obradović²,

M³

et al. 1985

Nuklearmedizin

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SummaryThe correlation between chemical formulation and biodistribution of 99mTc-phytate solutions was examined. On the basis of radiochemical analyses and biological experiments, the following optimum parameters were found: weight ratio of the anhydrous sodium phytate to SnCl2 18 : 1; concentration of phytate 5-6 g/1, pH of the injection solution 6-7. Maximum uptakes in rat organs were in the liver 95.8 ± 3.26 at 15-20 min p.i., and in the spleen 3.98 ± 0.79% 3 hours p. i. Two new methods for radiochemical analysis enabling the separation of three peaks were used: ITLC-SG Gelman chromatography and molecular sieving through Sephadex G-25. The bench-life of the injection solution was also checked during a 5-h period, as well as its shelf-life which was at least 6 months. Clinical examinations showed excellent visualization of the normal liver with discrete radiocolloid uptake in the spleen and no uptake in other tissues. With SPECT a more precise and clear localization of liver lesions was achieved especially due to the low uptake of 99mTc-phytate in the spleen.

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A Modified Tc-99m-Phytate Colloid for Liver–Spleen Imaging

Cited by 3 publications

References 21 publications

Sentinel lymph node identification with radiopharmaceuticals in patients with breast cancer: a comparison of 99mTc-tin colloid and 99mTc-phytate efficiency

Sentinel lymph node identification with radiopharmaceuticals in patients with breast cancer: a comparison of 99mTc-tin colloid and 99mTc-phytate efficiency

Novel Indocyanine Green–Phytate Colloid Technique for Sentinel Node Detection in Head and Neck: Mouse Study

Studies of the Chemical and Biological Properties of the Liver-Imaging Agent 99mTc-Phytate

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