A modified oral sugar test for evaluation of insulin and glucose dynamics in horses

Lindåse, Sanna; Nostell, Katarina; Askerfelt, Ida; Bröjer, Johan

doi:10.1186/1751-0147-57-s1-o4

Cited by 12 publications

(24 citation statements)

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“…In this small study population, only a dose of 0.45 mL/kg bwt of corn syrup allowed NL and PL ponies to be reliably distinguished compared with lower doses. The lower 0.15 mL/kg bwt dose was unable to distinguish between the two populations which contrasts to two previous studies [4,13], but is consistent with a third [7]. Only one single time point in our study, a blood sample at 60-min post-corn syrup administration allowed for the test to correctly assign all the individual ponies to their respective groups (NL and PL); time points either side of this failed to provide certainty.…”

Section: Discussioncontrasting

confidence: 82%

Effect of varying the dose of corn syrup on the insulin and glucose response to the oral sugar test

Jocelyn

Harries²,

Menzies‐Gow

2018

Equine Veterinary Journal

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Section: Discussioncontrasting

confidence: 82%

Effect of varying the dose of corn syrup on the insulin and glucose response to the oral sugar test

Jocelyn

Harries²,

Menzies‐Gow

2018

Equine Veterinary Journal

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“…A further OST using commercially available Scandinavian glucose syrup (Dan Sukker Glykossirap; Nordic Sugar A/S, Copenhagen, Denmark) has been described . A dosage of 0.2 mL/kg BM is comparable to corn syrup at 0.15 mL/kg, although reference ranges have not been established to date.…”

Section: Laboratory Diagnosismentioning

confidence: 99%

ECEIM consensus statement on equine metabolic syndrome

Durham¹,

Frank

McGowan

et al. 2019

Veterinary Internal Medicne

177

227

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Equine metabolic syndrome (EMS) is a widely recognized collection of risk factors for endocrinopathic laminitis. The most important of these risk factors is insulin dysregulation (ID). Clinicians and horse owners must recognize the presence of these risk factors so that they can be targeted and controlled to reduce the risk of laminitis attacks. Diagnosis of EMS is based partly on the horse's history and clinical examination findings, and partly on laboratory testing. Several choices of test exist which examine different facets of ID and other related metabolic disturbances. EMS is controlled mainly by dietary strategies and exercise programs that aim to improve insulin regulation and decrease obesity where present. In some cases, pharmacologic aids might be useful. Management of an EMS case is a long‐term strategy requiring diligence and discipline by the horse's carer and support and guidance from their veterinarians.

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“…The horses Equine Veterinary Journal 51 (2019) 733-737 © 2019 EVJ Ltd in the EMS group were examined at the University Equine Hospital at the Swedish University of Agricultural Sciences, whereas the control horses were examined at the Equine clinic, at the Swedish Horse Industry Foundation. An additional OST test was performed after the acclimatisation period where serial blood samples were collected after sugar administration [17]. The day after the OST, a euglycaemic hyperinsulinaemic clamp (EHC) was performed.…”

Section: Experimental Designmentioning

confidence: 99%

The effect of insulin infusion on heart rate and systemic blood pressure in horses with equine metabolic syndrome

Nostell

Lindåse

Edberg

et al. 2019

Equine Veterinary Journal

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Summary Background There is little evidence that horses with equine metabolic syndrome (EMS) have higher resting blood pressures than horses with normal insulin sensitivity. However, there are indications that EMS horses have an altered dynamic response to the cardiovascular effects of insulin. Objectives To examine heart rate and the systemic blood pressure response in EMS and control horses during insulin infusion. Study design Cross‐sectional study. Methods Horses were examined with an oral sugar test (OST) and a euglycaemic hyperinsulinaemic clamp (EHC). Based on the results from the OST, the horses were classified as either EMS or control. Blood pressure was measured before the start of the EHC and at 60, 120 and 180 min of the EHC. Results There were 16 EMS and 12 control horses. Mean resting heart rate was higher for EMS horses compared with control (35.6 ± 5.1 vs. 30.3 ± 3.5 beats/min). Systolic, diastolic and mean arterial blood pressure did not differ between groups at the start of the EHC. Blood pressure decreased gradually during the EHC in the control group, whereas the EMS group showed no decline in systolic, diastolic or mean arterial pressure. Main limitations Limited number of horses. Conclusions Horses with EMS have cardiovascular changes that affect resting heart rate and systemic blood pressure during insulin infusion.

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A modified oral sugar test for evaluation of insulin and glucose dynamics in horses

Cited by 12 publications

References 0 publications

Effect of varying the dose of corn syrup on the insulin and glucose response to the oral sugar test

Effect of varying the dose of corn syrup on the insulin and glucose response to the oral sugar test

ECEIM consensus statement on equine metabolic syndrome

The effect of insulin infusion on heart rate and systemic blood pressure in horses with equine metabolic syndrome

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