A modified dialyzer with vitamin E and antioxidant defense parameters

Mydlík, M; Derzsiová, K; Rácz, Olivér; Sipulova, Anna; Lovásová, Eva; Petrovicová, J

doi:10.1046/j.1523-1755.2001.07848.x

Cited by 12 publications

(15 citation statements)

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“…In the present study, supplementation with a combined vitamins C and E significantly elevated serum vitamin E, consistent with some studies [24][25][26][27], but its results are unlike Hultquist results [23].…”

Section: Discussionsupporting

confidence: 92%

“…Similar combined effect has been observed in the present study. After intervention, the reduction in the plasma MDA concentration, similar to previous studies [2,5,27,28] was in proportion to the increasing vitamins C and E levels.…”

Section: Discussionsupporting

confidence: 88%

“…In addition, the GPx activity was elevated, similar to the findings of Chao et al [28], Giray et al [5] and Mydlik et al [27].…”

Section: Discussionsupporting

confidence: 87%

“…After supplementation, significant increased of SOD activity is consistent with the previous reports [5], but it had not correspondence with Washio et al [26] and Mydlik et al data [27]. In addition, the GPx activity was elevated, similar to the findings of Chao et al [28], Giray et al [5] and Mydlik et al [27].…”

Section: Discussionsupporting

confidence: 64%

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Effect of combined vitamins C and E supplementation on oxidant/antioxidant status in hemodialysis patients

Montazerifar

Hashemi

Karajibani

et al. 2010

Mediterr J Nutr Metab

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The aim of this study was to evaluate the antioxidant supplementation effect on antioxidant system in hemodialysis patients. The study group consisted of 38 patients undergoing hemodialysis and 72 healthy subjects. The patients orally received combination of vitamins C (250 mg/time) and E (200 IU/time) three times per week for 2 months. Both, enzymatic antioxidants [superoxide dismutase (SOD) and glutathione peroxidase (GPx)] activities and non-enzymatic (vitamins E and C) levels and malondialdehyde (MDA) concentrations as lipid peroxidation product in patients were measured before and after supplementation compared with control group. The levels of antioxidants (vitamin E, C and SOD) (P \ 0.0001) and GPx (P \ 0.05) were significantly enhanced and MDA concentrations declined (P \ 0.0001) during the supplementation period. The study demonstrates that combined supplementation of vitamins C and E can noticeably affect antioxidant status and protect against oxidative stress caused during hemodialysis.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 88%

“…In addition, the GPx activity was elevated, similar to the findings of Chao et al [28], Giray et al [5] and Mydlik et al [27].…”

Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 64%

See 2 more Smart Citations

Effect of combined vitamins C and E supplementation on oxidant/antioxidant status in hemodialysis patients

Montazerifar

Hashemi

Karajibani

et al. 2010

Mediterr J Nutr Metab

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“…Also, a significant decrease in erythrocyte SOD activity even in HD patients treated only with rHuEpo was observed [11]. Contrariwise, Boran et al (quoted by Mydlik et al [20]) described a twofold increase of SOD and CAT activities in a group of erythropoietin-treated dialyzed patients compared to those who did not receive rHuEpo. A decreased generation of lipid peroxidation markers in HD patients receiving rHuEpo was also reported [3].…”

Section: Discussionmentioning

confidence: 99%

Influence of Epoietinum Therapy on the Oxidative Stress in Haemodialysis Patients

et al. 2005

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Background: The causes of oxidative stress in haemodialysis (HD) patients are still controversial. Beside the uraemic state and dialysis-related factors, adjuvant drug therapies such as epoietinum (rHuEpo) and intravenous iron were involved. Methods: Several parameters related to oxidative stress were assessed by spectrophotometry in stable HD patients, treated for at least 2 months with epoietinum (n = 14; mean dose = 97.7 ± 19.1 U/kg/week) or not (n = 15), none of them on iron therapy, and in 13 controls. Plasma thiobarbituric acid-reactive substances (TBARS) were used as markers of reactive species generation. Erythrocyte and plasma antioxidant systems, reflected by non-protein erythrocyte thiols, and erythrocyte enzyme activities – superoxide dismutase (SOD), glutathione peroxidase, catalase and plasma total thiols, respectively – were also investigated. Results: There were no differences between HD subgroups regarding haemoglobin levels. Plasma TBARS was increased in all HD patients as opposed to controls, irrespective of rHuEpo therapy. In addition, no change in antioxidant status parameters between rHuEpo-treated and -untreated patients was observed. Except for SOD, the other antioxidant indices were higher in all HD patients versus controls. Conclusions: These results suggest that (1) chronic HD patients appear to have simultaneously enhanced reactive species generation and antioxidative systems efficiency, and (2) epoietinum therapy did not change their oxidative status, at least in the absence of concomitant iron supplementation and at similar haemoglobin levels.

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Vitamin E Treatment Improves the Antioxidant Capacity of Patients Receiving Dialysis: A Systematic Review and Meta‐Analysis

Ni,

Zhou,

et al. 2023

Molecular Nutrition Food Res

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ScopeTo summarize the effect of vitamin E‐coated dialyzer membranes (VEMs) treatment or oral vitamin E intake on antioxidant molecules, such as superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT), and total antioxidant level in patients receiving dialysis.Methods and resultsA literature search of PubMed, Embase, CNKI, and the Cochrane Library databases is performed from inception to July 1, 2023, with no language nor country restrictions. Twenty‐four experimental studies involving 512 patients undergoing dialysis are selected for meta‐analysis. The levels of antioxidant markers in the blood of patients receiving hemodialysis (HD) improve with long‐term VEMs treatment (p = 0.016). According to the findings of each antioxidant index, there is a significant increase in the levels of erythrocyte‐derived SOD (p = 0.047), CAT (p = 0.029), and plasma‐derived total antioxidant level (p < 0.001). The antioxidant marker levels in patients receiving HD are significantly increased by oral vitamin E intake (p < 0.001). Erythrocyte‐derived SOD (p = 0.003), GPX (p < 0.001), and CAT (p = 0.001) substantially improves after 2–6 months of intervention with oral vitamin E preparation. The antioxidant index of patients receiving peritoneal dialysis (PD) is unaffected by oral vitamin E treatment (p = 0.945).ConclusionVitamin E therapy has a favorable effect on the retention of antioxidant compounds in patients undergoing dialysis.

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A modified dialyzer with vitamin E and antioxidant defense parameters

Cited by 12 publications

References 0 publications

Effect of combined vitamins C and E supplementation on oxidant/antioxidant status in hemodialysis patients

Effect of combined vitamins C and E supplementation on oxidant/antioxidant status in hemodialysis patients

Influence of Epoietinum Therapy on the Oxidative Stress in Haemodialysis Patients

Vitamin E Treatment Improves the Antioxidant Capacity of Patients Receiving Dialysis: A Systematic Review and Meta‐Analysis

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