A moderate red wine intake improves blood lipid parameters and erythrocytes membrane fluidity in post myocardial infarct patients

Abstract

While the cardioprotective effect of moderate and regular wine consumption in primary prevention has been well documented, the goal of the present investigation was to explore the effect of wine intake on blood parameters (lipid, anti-oxidant capacity, and erythrocyte membrane potential and fluidity) in post myocardial infarct patients to evaluate perspectives in secondary prevention. A clinical intervention trial has been undertaken on a group of selected post myocardial infarct patients who gave written informed consent for participation in this study prior to enrolment. This two-week study has been conducted on hospitalized patients during a cardiac readaptation period. During this period, patients were submitted to a "Western prudent" diet (inspired by the Mediterranean diet) and two groups have been compared on a drawn basis: patients receiving red wine (250 mL daily) to patients receiving water. Physical, clinical, and blood parameters were evaluated on Days 1 and 14. The data show a positive effect of low wine consumption on blood parameters (decrease in total cholesterol and LDL; increase in erythrocyte membrane fluidity and antioxidant status). The results show that a moderate consumption of red wine even for a short period associated with a "Western prudent" diet improves various blood parameters in lipid and anti-oxidative status in patients with previous coronary ischemic accidents.

Pro-oxidant activity of polyphenols and its implication on cancer chemoprevention and chemotherapy

“…Resveratrol, quercetin or the anthocyanins delphinidin and cyanidin are, among others polyphenols, involved in the cardiovascular benefits and cancer protective effects of a regular and moderated red wine consumption as shown in different epidemiological studies [42][43][44][45][46].…”

Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

“…reported positive associations while others reported negative associations (12)(13)(14)(15)(16)(17)(18)(19)(20)(21). 41…”

Cardioprotective effects of moderate red wine consumption: Polyphenols vs. ethanol

“…During this period, all subjects received a 'western prudent' diet, inspired by the Mediterranean diet principles. Moderate red wine intake reduced total cholesterol and LDLcholesterol, and improved erythrocyte membrane fluidity (Rifler et al, 2012).…”