a novel surgical approach for paraaortic lymphadenectomy with cervical cancer was started in our department, this surgical procedure has been performed with a new single-site approach exclusively via a single 2-to 3-cm left iliac incision. The patients were selected to record Body Mass Index (BMI), operative time, intraoperative blood loss, the number of paraaortic lymph node and positive lymph nodes, abdominal drainage tubes removal time, postoperative bowel function recovery time, total hospital stay time and perioperative complications. Measurements/Results: All 3 cases were successfully operated without conversion to laparotomy or conventional laparoscopy. The BMI (kg/m 2 ) was 20.4, 22.9 and 23.4; The operative time (min) was 140.6, 193.5 and 128.3; The intraoperative blood loss (ml) was 121, 109 and 95; The number of paraaortic lymph node dissections was 8, 13 and 15. All postoperative lymph node biopsy results were negative. The total hospital length of stay was from 7 to 13 days. No serious perioperative complications occurred. Conclusions: Single-site laparoscopic retroperitoneal para-aortic lymphadenectomy is feasible for cervical cancer treatment. However, due to limited cases, further evaluation regarding safety is warranted.
We developed novel closed-form estimators of genetic and environmental correlation coefficients. We applied them to estimate over 4,000 genetic and environmental correlations between multiple phenotypes in a diverse sample from the Trans-Omics in Precision Medicine (TOPMed) program. We found substantial differences in heritabilities, genetic, and environmental correlations of multiple phenotypes and phenotype-pairs between Black, Hispanic/Latino and White populations as well as between sexes. Finally, we quantified genetic and environmental correlations between phenotypic domains, each characterized by multiple phenotypes. Altogether we provide a novel, in-depth framework for examining relations among complex human phenotypes and their determinants.
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