MLD system is a type of hybrid system, which adopts the form of integer linear inequality including continuous variable and logical variable, which reflects both continuous and discrete dynamic characteristics by switching law. In this paper, the problem of optimal management of open laboratories in Colleges and universities is illustrated in the form of a class of advanced MLD system. By analyzing the main factors of laboratory consumption, the laboratory cost function is established. Taking the minimum cost as the objective function, it uses the random number of students in the laboratory to realize the energysaving optimization management of the laboratory. At the end of this paper, a simulation example is used to analyze the process of MLD system used in laboratory optimization management, which shows hybrid dynamic characteristics, optimal management effect and ideal applicability.