A Model of Long-Term Peritoneal Dialysis in the Dog

Abstract

We describe two preparations for chronic peritoneal dialysis in the dog. In one group uremia was induced by nephrectomy and in the other by ureteral ligation. Peritoneal access was obtained using the Ash disc column catheter. Survival of the animals ranged from 27 to 83 days. Using a dialysis schedule similar in concept to continuous ambulatory peritoneal dialysis in man we found that dialysate-induced ultrafiltration, equilibration of solute between serum and dialysate, as well as protein losses into dialysate approximated values found in patients undergoing continuous ambulatory peritoneal dialysis. Careful attention to detail is required in order to maintain these animals. The advantages of these models are their technical simplicity and prolonged survival making intermediate range studies feasible. Disadvantages include anemia, seen in the anephric animals, technical problems with the disc column catheter, the need for maintenance of strict aseptic technique when performing dialysis exchanges, and difficulties maintaining adequate nutrition.

Role of an Intraperitoneal Catheter Implant in the Pathogenesis of Experimental Staphylococcus epidermidis Peritoneal Infection in Renal Failure Mice

“…Utilizing this mouse model, studies done in our laboratory have previously demonstrated an immu nocompromised uremic host presenting reduced delayed-type hypersensitivity skin reaction [20][21][22] and increased susceptibility to bacterial challenge [ 13,23], The development of long-term peritoneal dialysis models, in animals having functional peritoneal cathe ters exiting through the skin, has been hindered by numerous complications. CAPD has been conducted in renal failure models in rabbits, dogs and rats for periods ranging from 2 days to 2 months [24][25][26], Additions to the peritoneal dialysis solutions included high concen trations of heparin to prevent fibrin clot formation and prophylactic antibiotics. Despite these preventive mea sures, management of these animals was frequently com plicated by peritoneal infection and obstruction of the peritoneal catheter.…”

Current techniques in peritoneal dialysis

“…However, technical problems with catheter flow and complications such as infection make chronic PD difficult. Few such cases have been reported …”

Peritoneal Dialysis

“…12,20,58,62,67 However, technical problems with catheter flow and complications such as infection make chronic PD difficult.…”