This Special Issue was proposed and supported by the Board of the American Psychosocial Oncology Society (APOS). Our esteemed Guest Editors were nominated by APOS to bring these papers together and reflect the special circumstances their members face, and indeed that are faced by psycho-oncology professionals globally, namely ensuring that psychosocial care is fully accepted and integrated, equally and without bias, as part of comprehensive cancer care.-.Maggie Watson, Editor-in-Chief This year, we have witnessed so much suffering as we have confronted the intersecting public health crises of the COVID-19 pandemic and systemic racism. Marginalized populations: Black, Latino, indigenous populations, older adults, individuals affected by poverty, disabilities, and mental illness, have experienced disproportionate burden from the pandemic. These populations have increased rates of infection, worse health outcomes, and encounter additional barriers to maintaining financial wellbeing and accessing care. We have experienced the impact of a health care system that is ill-prepared and ill-designed to meet the minimal health needs of underserved populations. As psycho-oncologists, we have seen our patients struggle with the decision to delay their cancer care and experience increased isolation and fear. As care delivery has rapidly transformed from in-person to virtual models, we are failing to reach the patients who likely need our interventions the most. Adults with low socioeconomic status, particularly older adults from marginalized populations, lack access to technology, are socially isolated, and must balance many competing needs.