A Model Based on Genetic Algorithm for Investigation of the Behavior of Rats in the Elevated Plus-Maze

Costa, Ariadne de Andrade; Roque, Antonio; Morato, Sílvio; Tinós, Renato

doi:10.1007/978-3-642-32639-4_19

Cited by 8 publications

(17 citation statements)

References 12 publications

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“…Some studies have shown that, after this period, rat's interest in the maze is naturally decreased (Montgomery, 1955). M a n u s c r i p t for the investigation of the behavior of rats in the EPM (Salum et al, 2000;Giddings, 2002;Miranda et al, 2009;Shimo et al, 2010;Tejada et al, 2010;Costa et al, 2012Costa et al, , 2013. One of the advantages of computational models is their ability to predict real phenomena.…”

Section: Introductionsupporting

confidence: 38%

“…The fitness function (Costa et al, 2012(Costa et al, , 2013 is composed by the weighted sum of a reward term (representing the curiosity of the rat) and a punishment term (representing its exposition to danger). The fitness function is given by:…”

Section: Model 1: Evolving Anns With Fixed Architecturementioning

confidence: 46%

“…Since 2012, we have been exploring neuroevolutionary models from a different perspective, where it is not necessary to employ data obtained from the trajectory of real rats to build the virtual rat (Costa et al, 2012(Costa et al, , 2013 In order to facilitate the study of rodent trajectories in the maze, the EPM arms are divided into equal positions (rectangles).…”

Section: Introductionmentioning

confidence: 45%

“…Investigating the best architectures for an ANN employed in the virtual rat can provide important insights about strategies used by the rats while navigating in the EPM. In the neuroevolutionary models (Costa et al, 2012(Costa et al, , 2013, the choice of the ANN's architecture is defined by the designer using heuristic rules and/or a trial and error approach. However, the number of possible architectures is huge, and, as a consequence, such approaches can result in unsatisfactory models.…”

Section: Introductionmentioning

confidence: 49%

See 3 more Smart Citations

Investigation of rat exploratory behavior via evolving artificial neural networks

Costa

Tinós

2016

Journal of Neuroscience Methods

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Section: Introductionsupporting

confidence: 38%

Section: Model 1: Evolving Anns With Fixed Architecturementioning

confidence: 46%

Section: Introductionmentioning

confidence: 45%

Section: Introductionmentioning

confidence: 49%

See 2 more Smart Citations

Investigation of rat exploratory behavior via evolving artificial neural networks

Costa

Tinós

2016

Journal of Neuroscience Methods

Self Cite

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“…Curiosamente, dentre todos os trabalhos publicados envolvendo ratos no LCE, apenas nove exploraram modelos computacionais, de acordo com o conhecimento da autora [18,19,20,21,22,23,24,25,26] [67]. Os elementos que atuam na população, por exemplo selecionando-a ou modificando-a, são chamados de operadores.…”

Section: Estrutura Da Teseunclassified

Investigação de modelos comportamentais de ratos por meio de algoritmos genéticos

Costa¹

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Examining Anxiety and Risk-taking in Healthy Male and Female Wistar Rats using Spatial and Temporal Analysis of Elevated Plus Maze

Sharma¹,

Pandey²,

Jain

et al. 2022

Preprint

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The Elevated Plus Maze (EPM) offers a standard set up for understanding anxiety, unconditioned risk-avoidance in rodents. The animal shows a preference for enclosed safe arms and avoids risky, open arms that evoke anxiety due to elevated platform (unconditioned response to elevation). A few rodent studies aiming to understand sex-skewed representation in anxiety disorders use the maze and report that more females compared to males show high levels of anxiety and risk-avoidance on an elevated platform. Ethograms derived from examining animal behaviour in the EPM provide precise measures of behaviour of interest, enabling objective assessment of anxiety and risk behaviour. We report two new parameters that might be critical for quantitative analysis of EPM task as a measure of anxiety with reference to sex-differences in risk-taking: (a) spatial preference for arms (open & closed) (b) temporal shift in arm preference in task trials. We first report results from the conventionally derived measures confirming that males spent more time in the open arms indicating low anxiety and higher risk-taking. Preferences for the two open and two closed arms were non-uniform for males and females; male showed stronger preference for one of the two risky open arms, and females showed a stronger preference for one of the two safe closed arms. Temporal analyses indicated that males spent more time in open arms in 3 out of 6 time bins (time blocks), and females spent more time in the closed arms in 5 out of 6 time bins (time blocks), however, counter-intuitively, females showed larger increase in time spent in open arms in the last phase potentially indicating greater regulation of anxiety and increased risk-taking. Inclusion of spatial and temporal parameters in EPM studies might improve our understanding of cognitive and biological sex differences pertaining to anxiety, and risky behavior.

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A Model Based on Genetic Algorithm for Investigation of the Behavior of Rats in the Elevated Plus-Maze

Cited by 8 publications

References 12 publications

Investigation of rat exploratory behavior via evolving artificial neural networks

Investigation of rat exploratory behavior via evolving artificial neural networks

Investigação de modelos comportamentais de ratos por meio de algoritmos genéticos

Examining Anxiety and Risk-taking in Healthy Male and Female Wistar Rats using Spatial and Temporal Analysis of Elevated Plus Maze

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