A Mo(<scp>vi</scp>) based coordination polymer as an antiproliferative agent against cancer cells

Joshi, Arti; Gupta, Ruby; Sharma, Deepika; Singh, Monika

doi:10.1039/d0dt03865b

Cited by 6 publications

(5 citation statements)

References 48 publications

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“…26 Buczkowska et al 27 performed a comprehensive study about cytotoxic and antimicrobial activities of Cu (II), Co (II), Pt (II), and Zn (II) complexes with N,O-chelating heterocyclic carboxylates and reported that these complexes have interesting cytotoxic activities in various human cancer cell lines. A molybdenum complex of pyridine-2-carboxylic acid synthesized by Joshi et al 28 and quite promising inhibitory effect against HepG2 (human liver cancer), A549 (human lung cancer), and MCF-7 (human breast cancer) cell lines, respectively, have been found.…”

Section: Introductionmentioning

confidence: 99%

Experimental and theoretical approaches on structural, spectroscopic (FT‐IR and UV‐Vis), nonlinear optical, and molecular docking analyses for Zn (II) and Cu (II) complexes of 6‐chloropyridine‐2‐carboxylic acid

Dege

Tamer

Şimşek

et al. 2022

Applied Organom Chemis

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Novel transition metal-based complexes that may be of value as biological agents and/or nonlinear optical materials, Zn (II) and Cu (II) transition metal complexes of 6-chloropyridine-2-carboxylic acid (LH), were successfully synthesized. The chemical structure of each complex was characterized using Xray diffraction (XRD) method and FT-IR spectroscopy. XRD and FT-IR demonstrated that L ligand coordinate to central metal ions through the donor N and O atoms. By coordinating two H 2 O ligand to Zn (II) ion, a distorted octahedral complex geometry was constructed for 1. As for 2, a distorted trigonal bipyramidal coordination geometry was obtained by a H 2 O ligand coordination to Cu (II) ion. Theoretical studies using B3LYP/6-311++G(d,p)-LanL2DZ were performed to further validate the proposed structures. The molecular docking of 1 to SARS-CoV-2 main protease (PDB: 6LU7) gives a binding energy of À5.24 kcal/mol and inhibition constant of 144.6 μM, demonstrating that 1 is a more promising candidate to biologically active complexes than 2. The firstorder hyperpolarizability (β) parameter for 1 and 2 was calculated as 0.88 Â 10 À30 and 10.40 Â 10 À30 esu, respectively. These β values also demonstrated that 2 exhibits more effective NLO character than 1 due to the electronic configuration and coordination geometry.

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Section: Introductionmentioning

confidence: 99%

Experimental and theoretical approaches on structural, spectroscopic (FT‐IR and UV‐Vis), nonlinear optical, and molecular docking analyses for Zn (II) and Cu (II) complexes of 6‐chloropyridine‐2‐carboxylic acid

Dege

Tamer

Şimşek

et al. 2022

Applied Organom Chemis

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“…The stability study was done by using a UV-visible spectrophotometer for 72 h at various time intervals for (C 6 H 16 N)(C 6 H 15 N) 2 [Mo 8 O 26 ]·3H 2 O, 1. The UV-visible spectrum exhibits an intense absorption band at 207 nm attributed to the π–π* charge transfer transitions of the O t –Mo 60 bond (where O t is a terminal oxygen) and another band at 230 nm assigned to the charge transfer transition of O d → Mo 52 (where O d is bridging oxygen). The solution of the synthesized solid 1 in PBS buffer was monitored for 72 h during which no peak disappearance or shift or appearance of a new peak was observed as shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…11,51 So in some of the reports DNA interaction with POM was elucidated to be the mechanism of anticancer activity. 6,11,48,52,53 Few more mechanisms of antitumor activity were found to be inhibition of angiogenesis and interaction of polyoxometalate with proteins. 4,6 Herein, we have reported a b-octamolybdate type of POM cluster functionalized with triethyl amine molecules 1), and its structural composition was investigated by single crystal X-ray diffraction followed by other subsequent characterization techniques such as powder X-ray diffraction, FTIR, electron microscopy analysis (FESEM and TEM), X-ray photoelectron spectroscopy (XPS) and thermogravimetric analysis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A polyoxomolybdate-based hybrid nano capsule as an antineoplastic agent

Joshi,

Acharya,

Devi

et al. 2023

Nanoscale Adv.

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“…With M = Mo, a triclinic phase ( n = 0.5) along with a small amount of a cubic phase ( n = 0) were obtained. These materials hold potential as CORMAs due to the presence of pyz fragments as core components in many approved and investigational drugs, the favorable safety profile of pyz and derivatives as food additives, the essential role played by molybdenum as a cofactor for several enzymes in human metabolism, , the low toxicity of molybdenum metabolites, − and the proven efficacy of molecular tricarbonyl complexes as CORMs. , In the present work, we set out to optimize individual syntheses of the two crystalline fac -Mo(CO) 3 (pyz) 3/2 phases. Once this was achieved, we were able to evaluate the CO-release behavior of the MOFs, showing that they behave as CORMAs.…”

Section: Introductionmentioning

confidence: 99%

Tricarbonyl-Pyrazine-Molybdenum(0) Metal–Organic Frameworks for the Storage and Delivery of Biologically Active Carbon Monoxide

Silva

Calhau

Gomes

et al. 2023

ACS Biomater. Sci. Eng.

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Metal–organic frameworks (MOFs) have high potential as nanoplatforms for the storage and delivery of therapeutic gasotransmitters or gas-releasing molecules. The aim of the present study was to open an investigation into the viability of tricarbonyl-pyrazine-molybdenum(0) MOFs as carbon monoxide-releasing materials (CORMAs). A previous investigation found that the reaction of Mo(CO)6 with excess pyrazine (pyz) in a sealed ampoule gave a mixture comprising a major triclinic phase with pyz-occupied hexagonal channels, formulated as fac-Mo(CO)3(pyz)3/2·1/2pyz (Mo-hex), and a minor dense cubic phase, formulated as fac-Mo(CO)3(pyz)3/2 (Mo-cub). In the present work, an open reflux method in toluene has been optimized for the large-scale synthesis of the pure Mo-cub phase. The crystalline solids Mo-hex and Mo-cub were characterized by powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), FT-IR and FT-Raman spectroscopies, and 13C{1H} cross-polarization (CP) magic-angle spinning (MAS) NMR spectroscopy. The release of CO from the MOFs was studied by the deoxy-myoglobin (deoxy-Mb)/carbonmonoxy-myoglobin (MbCO) UV–vis assay. Mo-hex and Mo-cub release CO upon contact with a physiological buffer in the dark, delivering 0.35 and 0.22 equiv (based on Mo), respectively, after 24 h, with half-lives of 3–4 h. Both materials display high photostability such that the CO-releasing kinetics is not affected by irradiation of the materials with UV light. These materials are attractive as potential CORMAs due to the slow release of a high CO payload. In the solid-state and under open air, Mo-cub underwent almost complete decarbonylation over a period of 4 days, corresponding to a theoretical CO release of 10 mmol per gram of material.

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A Mo(vi) based coordination polymer as an antiproliferative agent against cancer cells

Abstract: A Mo(vi) based coordination polymer (CP 1) has been synthesized under mild conditions. CP 1 possesses good aqueous stability and it shows efficient antitumoral activity against MCF-7, A549 and HepG2 cancer cells.

Cited by 6 publications

References 48 publications

Experimental and theoretical approaches on structural, spectroscopic (FT‐IR and UV‐Vis), nonlinear optical, and molecular docking analyses for Zn (II) and Cu (II) complexes of 6‐chloropyridine‐2‐carboxylic acid

Experimental and theoretical approaches on structural, spectroscopic (FT‐IR and UV‐Vis), nonlinear optical, and molecular docking analyses for Zn (II) and Cu (II) complexes of 6‐chloropyridine‐2‐carboxylic acid

A polyoxomolybdate-based hybrid nano capsule as an antineoplastic agent

Tricarbonyl-Pyrazine-Molybdenum(0) Metal–Organic Frameworks for the Storage and Delivery of Biologically Active Carbon Monoxide

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