A mitochondria targeting artesunate prodrug-loaded nanoparticle exerting anticancer activity<i>via</i>iron-mediated generation of the reactive oxygen species

Chen, Zhigang; Kang, Xiaoming; Wu, Yi-Ting; Xiao, Haihua; Cai, Xuzi; Sheng, Shihou; Wang, Xuefeng; Chen, Shiguo

doi:10.1039/c9cc00531e

Cited by 24 publications

(16 citation statements)

References 28 publications

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“…Chen et al prepared conjugates of artesunate incorporated to a long chain of N , N ′-bis(dodecyl)- l -glutamic diamide. The formulation mediated ROS generation and targeted the mitochondria, a target for inducing cancer cell death and bypassing multi-drug resistance (MDR) mechanisms [ 123 ]. Liu et al developed artesunate-loaded bovine serum albumin nanoparticles for mitochondrial targeting.…”

Section: Nanoparticlesmentioning

confidence: 99%

Nanoparticles Formulations of Artemisinin and Derivatives as Potential Therapeutics for the Treatment of Cancer, Leishmaniasis and Malaria

Alven

Aderibigbe

2020

Pharmaceutics

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Cancer, malaria, and leishmaniasis remain the deadly diseases around the world although several strategies of treatment have been developed. However, most of the drugs used to treat the aforementioned diseases suffer from several pharmacological limitations such as poor pharmacokinetics, toxicity, drug resistance, poor bioavailability and water solubility. Artemisinin and its derivatives are antimalarial drugs. However, they also exhibit anticancer and antileishmanial activity. They have been evaluated as potential anticancer and antileishmanial drugs but their use is also limited by their poor water solubility and poor bioavailability. To overcome the aforementioned limitations associated with artemisinin and its derivatives used for the treatment of these diseases, they have been incorporated into nanoparticles. Several researchers incorporated this class of drugs into nanoparticles resulting in enhanced therapeutic outcomes. Their potential efficacy for the treatment of parasitic infections such as malaria and leishmaniasis and chronic diseases such as cancer has been reported. This review article will be focused on the nanoparticles formulations of artemisinin and derivatives for the treatment of cancer, malaria, and leishmaniasis and the biological outcomes (in vitro and in vivo).

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Section: Nanoparticlesmentioning

confidence: 99%

Nanoparticles Formulations of Artemisinin and Derivatives as Potential Therapeutics for the Treatment of Cancer, Leishmaniasis and Malaria

Alven

Aderibigbe

2020

Pharmaceutics

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“…Wang applied core-shell structured nanoparticles to encapsulate artemisinin and ultrasound (1 MHz, 2W/cm 2 ) was employed to realize drug procedural controlled release and cancer sonodynamic combined therapy [ 42 ]. ART kills tumor cells by promoting protein alkylation and blocking cell cycle [ [44] , [45] , [46] ]. The use of ART as an oxygen-independent sonosensitizer for ROS production would eliminate the oxygen-deficient problem for SDT in hypoxic tumor environments.…”

Section: Introductionmentioning

confidence: 99%

Multiple stimuli-responsive nanosystem for potent, ROS-amplifying, chemo-sonodynamic antitumor therapy

Tang

Cheng

Liu

et al. 2022

Bioactive Materials

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“…In addition, mitochondria were one of the most vital organelles and involved in many physical processes such as metabolism and apoptosis . Mitochondria were vulnerable to ROS, so modifying some mitochondrial targeting molecules, such as small molecules and polypeptides, could enhance the therapeutic effect of ROS. − (3-Carboxypropyl)triphenylphosphonium bromide (TPP) was widely used as a target molecule of mitochondria. In a word, FA and TPP were excellent target agents and could lead to a specific distribution, bringing negligible side effects and brilliant therapeutic effects of tumors.…”

Section: Introductionmentioning

confidence: 99%

Phosphate-Degradable Nanoparticles Based on Metal–Organic Frameworks for Chemo-Starvation-Chemodynamic Synergistic Antitumor Therapy

Peng

Qin

Feng

et al. 2021

ACS Appl. Mater. Interfaces

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Chemodynamic therapy (CDT) was regarded as a promising approach for tumor treatment. However, owing to the insufficient amount of endogenous hydrogen peroxide (H2O2) in tumor cells, the efficacy of CDT was limited. In this study, we designed phosphate-responsive nanoparticles (denoted as MGDFT NPs) based on metal–organic frameworks, which were simultaneously loaded with drug doxorubicin (DOX) and glucose oxidases (GOx). The decorated GOx could act as a catalytic nanomedicine for the response to the abundant glucose in the tumor microenvironment, generating a great deal of H2O2, which would enhance the Fenton reaction and produce toxic hydroxyl radicals (·OH). Meanwhile, the growth of tumors would also be inhibited by overconsuming the intratumoral glucose, which was the “fuel” for cell proliferation. When the nanoparticles entered into tumor cells, a high concentration of phosphate induced structure collapse, releasing the loaded DOX for chemotherapy. Furthermore, the decoration of target agents endowed the nanoparticles with favorable target ability to specific tumor cells and mitochondria. Consequently, the designed MGDFT NPs displayed desirable synergistic therapeutic effects via combining chemotherapy, starvation therapy, and enhanced Fenton reaction, facilitating the development of multimodal precise antitumor therapy.

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A mitochondria targeting artesunate prodrug-loaded nanoparticle exerting anticancer activityviairon-mediated generation of the reactive oxygen species

Abstract: An artesunate anticancer prodrug with a long aliphatic chain N,N′-bis(dodecyl)-l-glutamic diamide was developed for nanoparticle via iron-mediated ROS generation.

Cited by 24 publications

References 28 publications

Nanoparticles Formulations of Artemisinin and Derivatives as Potential Therapeutics for the Treatment of Cancer, Leishmaniasis and Malaria

Nanoparticles Formulations of Artemisinin and Derivatives as Potential Therapeutics for the Treatment of Cancer, Leishmaniasis and Malaria

Multiple stimuli-responsive nanosystem for potent, ROS-amplifying, chemo-sonodynamic antitumor therapy

Phosphate-Degradable Nanoparticles Based on Metal–Organic Frameworks for Chemo-Starvation-Chemodynamic Synergistic Antitumor Therapy

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