A mitochondria-targeted anticancer copper dithiocarbamate amplifies immunogenic cuproptosis and macrophage polarization

Lu, Yao; Fan, Xi; Pan, Qingqing; He, Bin; Pu, Yuji

doi:10.1039/d3tb02886k

J. Mater. Chem. B

2024

DOI: 10.1039/d3tb02886k

|View full text |Cite

A mitochondria-targeted anticancer copper dithiocarbamate amplifies immunogenic cuproptosis and macrophage polarization

Yao Lu,

Xi Fan,

Qingqing Pan

et al.

Abstract: The way that cancer cells die inspires treatment regimens and cytolytic cuproptosis induced by copper complexes, like copper(II) bis(diethyldithiocarbamate) (CuET), emerges as a novel therapeutic target. Herein, a triphenylphosphonium-modified CuET...

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 6 publications

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Cuproptosis and Cuproptosis‐Based Synergistic Therapy for Cancer Treatment

Shen,

Qiu,

Ding

et al. 2024

ChemMedChem

View full text Add to dashboard Cite

Copper, as an essential trace nutrient for human, plays a crucial role in numerous cellular activities, and is vital for maintaining homeostasis in organisms. Deviations from normal intracellular copper concentration range can disrupt the cellular homeostasis and lead to cell death. Cell death is the process in which cells lose their vitality and cannot sustain normal metabolism, which has various forms. The recently discovered cuproptosis mechanism differs from the previously recognized forms, which is triggered by intracellular copper accumulation. The discovery of cuproptosis has sparked interest among researchers, and this mechanism has been applied in the treatment of various intractable diseases, including different types of cancer. However, the developed cuproptosis‐based therapies have revealed certain limitations, such as low immunostimulatory efficiency, poor tumor targeting, and inhibition by the tumor microenvironment. Therefore, researchers are devoted to combining cuproptosis with existing cancer therapies to develop more effective synergistic cancer therapies. This review summarizes the latest research advancements in the cuproptosis‐based therapies for various types of cancer, with a focus on the synergistic cancer therapies. Finally, it provides an outlook on the future development of cuproptosis in anti‐tumor therapy.

show abstract

Cuproptosis and Cuproptosis‐Based Synergistic Therapy for Cancer Treatment

Shen,

Qiu,

Ding

et al. 2024

ChemMedChem

View full text Add to dashboard Cite

show abstract

Targeting cuproptosis for cancer therapy: Focus on the anti-tumor immune system

Zhang,

Han

2024

Cancer Pathogenesis and Therapy

View full text Add to dashboard Cite

Cardiovascular disease: Mitochondrial dynamics and mitophagy crosstalk mechanisms with novel programmed cell death and macrophage polarisation

Liu,

Qin,

Gao

et al. 2024

Pharmacological Research

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

A mitochondria-targeted anticancer copper dithiocarbamate amplifies immunogenic cuproptosis and macrophage polarization

Abstract: The way that cancer cells die inspires treatment regimens and cytolytic cuproptosis induced by copper complexes, like copper(II) bis(diethyldithiocarbamate) (CuET), emerges as a novel therapeutic target. Herein, a triphenylphosphonium-modified CuET...

Cited by 6 publications

References 43 publications

Cuproptosis and Cuproptosis‐Based Synergistic Therapy for Cancer Treatment

Cuproptosis and Cuproptosis‐Based Synergistic Therapy for Cancer Treatment

Targeting cuproptosis for cancer therapy: Focus on the anti-tumor immune system

Cardiovascular disease: Mitochondrial dynamics and mitophagy crosstalk mechanisms with novel programmed cell death and macrophage polarisation

Contact Info

Product

Resources

About