A mini mass spectrometer with a low noise Faraday detector

Tang, Yang; Xu, Qiu; Li, Dayu; Xu, Wei

doi:10.1039/d0an00420k

Cited by 8 publications

(6 citation statements)

References 49 publications

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“…Simultaneously monitoring multiple ion beams enabled the detection of isotopic ratios of analytes [132]. Tang et al [133] described a low noise Faraday cup and implemented it in a miniaturized mass spectrometer. This design included a circuit board with a metal disc to collect ions and a shielding shell that served as a preamplifier to inhibit electrical interferences.…”

Section: Detectormentioning

confidence: 99%

Portable mass spectrometry system: instrumentation, applications, and path to ‘omics analysis

et al. 2022

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Mass spectrometry (MS) is an information rich analytical technique and plays a key role in various 'omics studies. Standard mass spectrometers are bulky and operate at high vacuum, which hinder their adoption by the broader community and utility in field applications. Developing portable mass spectrometers can significantly expand the application scope and user groups of MS analysis. This review discusses the basics and recent advancements in the development of key components of portable mass spectrometers including ionization source, mass analyzer, detector, and vacuum system. Further, major areas where portable mass spectrometers are applied are also discussed. Finally, a perspective on the further development of portable mass spectrometers including the potential benefits for 'omics analysis is provided.

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Section: Detectormentioning

confidence: 99%

Portable mass spectrometry system: instrumentation, applications, and path to ‘omics analysis

et al. 2022

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“…Review a zirconocene polymerization catalyst. 14 There are efforts toward the development of miniaturized spectrometers 156 and coupling microfluidic chips to traditional mass spectrometers. 157,158 However, interfacing microfluidic chips for real-time online analysis still represents a challenge.…”

Section: Intelligent Microfluidics In Materials Discovery and Synthesismentioning

confidence: 99%

Intelligent Microfluidics: The Convergence of Machine Learning and Microfluidics in Materials Science and Biomedicine

Galan

Zhao

Wang

et al. 2020

Matter

104

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“…However, the addition of shunt capacitors lowers the Q factor of the resonant circuit, leading to a trade-off between efficiency and output voltage. Recently, a miniature mass spectrometer capable of analyzing native proteins was constructed by shrinking the radius of an ion trap, allowing for a mass range of up to 6500 Th. , Nevertheless, it was difficult to further reduce the resonant frequency after lowering it from 930 to 520 kHz by adding shunt capacitors. Although a dedicated resonant circuit can be designed for low frequencies, this would completely prevent the detection of low-mass ions.…”

Section: Introductionmentioning

confidence: 99%

Development of a High-Field “Brick” Mass Spectrometer with Extended Mass Range and Capable of Characterizing Native Proteins

Zhang,

Jia,

Hong

et al. 2023

Anal. Chem.

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One of the main challenges of analyzing intact proteins on an ion trap mass spectrometer is the mass range limitation, especially for miniature mass spectrometers. In this study, a high-field frequency scanning ion trap miniature mass spectrometer, namely the high-field "Brick" mass spectrometer, was developed to analyze intact proteins. A high-voltage broadband radio frequency (rf) amplifier was designed with a maximum output of 900 V p-p over a frequency range of 130−700 kHz. Compared to the 600 V p-p rf amplifier equipped in the conventional "Brick" mass spectrometer, the mass range of the instrument could be extended from 2000 to over 8000 Th. Sensitivity and mass resolution for native protein analyses were also evaluated and compared. Various proteins as well as their mixtures were analyzed on the high-field "Brick" mass spectrometer. The noncovalent interaction between protein−ligand complexes, lysozyme with triN-acetylchitotriose, was also analyzed. In addition, a hybrid ion scan mode was explored to further expand the mass range of the instrument at both low-and high-mass ends. In the hybrid ion scan mode, both rf frequency and amplitude were tuned, and a mass range from 100 to 12,000 Th was realized. As a result, both small drugs and proteins could be analyzed in a single mass scan. As proof-of-concept demonstrations, a mixture of atenolol and bovine serum albuminand oligomers of transferrin were analyzed.

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A mini mass spectrometer with a low noise Faraday detector

Abstract: A low noise Faraday detector and a data processing method were developed for a miniature ion trap mass spectrometer.

Cited by 8 publications

References 49 publications

Portable mass spectrometry system: instrumentation, applications, and path to ‘omics analysis

Portable mass spectrometry system: instrumentation, applications, and path to ‘omics analysis

Intelligent Microfluidics: The Convergence of Machine Learning and Microfluidics in Materials Science and Biomedicine

Development of a High-Field “Brick” Mass Spectrometer with Extended Mass Range and Capable of Characterizing Native Proteins

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