A million persons, a million dreams: a vision for a national center of radiation epidemiology and biology

Boice, John D.; Quinn, Brian; Al-Nabulsi, Isaf; Ansari, Armin; Blake, Paul K; Blattnig, Steve R.; Caffrey, Emily; Cohen, Sarah S.; Golden, Ashley P.; Held, Kathryn D.; Jokisch, Derek W.; Leggett, Richard W.; Mumma, Michael T.; Samuels, Caleigh; Till, John E.; Tolmachev, Sergei Y.; Yoder, R.C.; Zhou, Joey Y.; Dauer, Lawrence T.

doi:10.1080/09553002.2021.1988183

Cited by 36 publications

(41 citation statements)

References 119 publications

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“…Moreover, studies in mice demonstrated that exposure to a much lower dose (0.1 Gy) could lead to the downregulation of neurotransmitters and genes with functions in synapses and neuron projections [ 30 , 31 ]. These results support the notion that the cellular response to chronic low dose and high dose and dose rates are different and further describe the emerging evidence of the neurological effects of exposure to radiation at dose rates much lower than previously thought in humans [ 29 , 32 , 33 , 34 ].…”

Section: Introductionsupporting

confidence: 87%

Revealing the Increased Stress Response Behavior through Transcriptomic Analysis of Adult Zebrafish Brain after Chronic Low to Moderate Dose Rates of Ionizing Radiation

Cantabella

Camilleri

Cavalié

et al. 2022

Cancers

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High levels of ionizing radiation (IR) are known to induce neurogenesis defects with harmful consequences on brain morphogenesis and cognitive functions, but the effects of chronic low to moderate dose rates of IR remain largely unknown. In this study, we aim at defining the main molecular pathways impacted by IR and how these effects can translate to higher organizational levels such as behavior. Adult zebrafish were exposed to gamma radiation for 36 days at 0.05 mGy/h, 0.5 mGy/h and 5 mGy/h. RNA sequencing was performed on the telencephalon and completed by RNA in situ hybridization that confirmed the upregulation of oxytocin and cone rod homeobox in the parvocellular preoptic nucleus. A dose rate-dependent increase in differentially expressed genes (DEG) was observed with 27 DEG at 0.05 mGy/h, 200 DEG at 0.5 mGy/h and 530 DEG at 5 mGy/h. Genes involved in neurotransmission, neurohormones and hypothalamic-pituitary-interrenal axis functions were specifically affected, strongly suggesting their involvement in the stress response behavior observed after exposure to dose rates superior or equal to 0.5 mGy/h. At the individual scale, hypolocomotion, increased freezing and social stress were detected. Together, these data highlight the intricate interaction between neurohormones (and particularly oxytocin), neurotransmission and neurogenesis in response to chronic exposure to IR and the establishment of anxiety-like behavior.

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Section: Introductionsupporting

confidence: 87%

Revealing the Increased Stress Response Behavior through Transcriptomic Analysis of Adult Zebrafish Brain after Chronic Low to Moderate Dose Rates of Ionizing Radiation

Cantabella

Camilleri

Cavalié

et al. 2022

Cancers

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“…The Million Person Study consists of five categories of workers and veterans exposed to radiation from 1939 to the present. Different from the case for Japanese atomic bomb survivors, MPS is to provide scientifically valid information on the level of radiation risk when exposures are received gradually over time and not within seconds [130 , 131] . INWORKS and MPS provide an illuminating insight into the possible range and assessment of carcinogenic effects following low dose-rate radiation exposure.…”

Section: Cancer Risk Assessment Of Space Radiationmentioning

confidence: 99%

Carcinogenesis induced by space radiation: A systematic review

Guo

Zhou

2022

Neoplasia

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“…Yet, individual cohorts of workers in the United States occupationally exposed to ionizing radiation, including workers at the Los Alamos National Laboratory and medical radiation workers, did not report any ionizing radiation-related increases in mortality from dementia, Alzheimer’s disease, Parkinson’s disease and other motor neuron diseases ( Boice et al, 2021a ; 2021b ). However, additional analysis including the evaluation of combined cohorts of occupationally exposed individuals with updated dosimetry that will assess the ionizing radiation-related risks for neurodegenerative diseases including dementia and Parkinson’s disease are forthcoming ( Boice et al, 2021c ).…”

Section: Evidence Base Describing the Impact Of Ionizing Radiation On...mentioning

confidence: 99%

Ionizing radiation, cerebrovascular disease, and consequent dementia: A review and proposed framework relevant to space radiation exposure

Miller

Mi²,

Nelson³

et al. 2022

Front. Physiol.

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Space exploration requires the characterization and management or mitigation of a variety of human health risks. Exposure to space radiation is one of the main health concerns because it has the potential to increase the risk of cancer, cardiovascular disease, and both acute and late neurodegeneration. Space radiation-induced decrements to the vascular system may impact the risk for cerebrovascular disease and consequent dementia. These risks may be independent or synergistic with direct damage to central nervous system tissues. The purpose of this work is to review epidemiological and experimental data regarding the impact of low-to-moderate dose ionizing radiation on the central nervous system and the cerebrovascular system. A proposed framework outlines how space radiation-induced effects on the vasculature may increase risk for both cerebrovascular dysfunction and neural and cognitive adverse outcomes. The results of this work suggest that there are multiple processes by which ionizing radiation exposure may impact cerebrovascular function including increases in oxidative stress, neuroinflammation, endothelial cell dysfunction, arterial stiffening, atherosclerosis, and cerebral amyloid angiopathy. Cerebrovascular adverse outcomes may also promote neural and cognitive adverse outcomes. However, there are many gaps in both the human and preclinical evidence base regarding the long-term impact of ionizing radiation exposure on brain health due to heterogeneity in both exposures and outcomes. The unique composition of the space radiation environment makes the translation of the evidence base from terrestrial exposures to space exposures difficult. Additional investigation and understanding of the impact of low-to-moderate doses of ionizing radiation including high (H) atomic number (Z) and energy (E) (HZE) ions on the cerebrovascular system is needed. Furthermore, investigation of how decrements in vascular systems may contribute to development of neurodegenerative diseases in independent or synergistic pathways is important for protecting the long-term health of astronauts.

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A million persons, a million dreams: a vision for a national center of radiation epidemiology and biology

Cited by 36 publications

References 119 publications

Revealing the Increased Stress Response Behavior through Transcriptomic Analysis of Adult Zebrafish Brain after Chronic Low to Moderate Dose Rates of Ionizing Radiation

Revealing the Increased Stress Response Behavior through Transcriptomic Analysis of Adult Zebrafish Brain after Chronic Low to Moderate Dose Rates of Ionizing Radiation

Carcinogenesis induced by space radiation: A systematic review

Ionizing radiation, cerebrovascular disease, and consequent dementia: A review and proposed framework relevant to space radiation exposure

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