A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides

Abstract

Radi, M. (2016). A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides. TETRAHEDRON LETTERS. DOI: 10.1016DOI: 10. /j.tetlet.2016 Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections. General rightsCopyright and moral rights for the publications made accessible in the Research Portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognize and abide by the legal requirements associated with these rights.•Users may download and print one copy of any publication from the Research Portal for the purpose of private study or research.•You may not further distribute the material or use it for any profit-making activity or commercial gain •You may freely distribute the URL identifying the publication in the Research Portal Take down policyIf you believe that this document breaches copyright please contact librarypure@kcl.ac.uk providing details, and we will remove access to the work immediately and investigate your claim.

Recent Advances in the Microwave Assisted Synthesis of Benzofuran and Indole Derivatives

“…Radi et al succeeded in achieving substituted benzofuran-2-carboxamides via microwave assisted multi-component reaction of anilines, α-chloroacetyl chloride and 2'hydroxyacetophenones. 36 The reaction exhibited good functional group tolerance under the optimized conditions (Cs2CO3 as base, in dry DMF upon microwave irradiation at 140 °C) (Scheme 1). When electron-donating substituents were attached to 2'-hydroxyacetophenones, the yield of the corresponding product got reduced rapidly.…”

Advances in Synthetic Strategies and Medicinal Importance of Benzofurans: A Review

“…This step was followed by treating 3 with triphenylphosphine to give phosphonium salt (36) with dry benzene as solvent and refluxed for five hours. Reacting these salts with various benzoyl chloride (37) and methyl/formyl chloride (39) under reflux in toluene in attendance of triethylamine as base results in formation of title compounds represented in Scheme 3 and Scheme 4. [37] Qiu et al synthesized small molecule that is asymmetric named as R3T-TBFO (Scheme 5) based on thieno[2,3f]benzofuran.…”

Recent Advances in Microwave Assisted Multicomponent Reactions

“…A diversity oriented multicomponent protocol for the synthesis of benzofuran‐2‐carboxamides was established by Paolo et al . Several substituted furans such as 3‐aminobenzofurans, 3‐alkylbenzofurans, and 3‐unsubstituted benzofurans were synthesised from 2′‐hydroxyacetophenones, benzonitriles, aldehydes and readily available amines.…”