Microwave (MW) assisted multicomponent reactions (MCRs) provide facile and expeditious procedures for the synthesis of several diversely functionalised molecules. Significant enhancement in selectivity, purity and reproducibility is offered by this process. Shorter reaction times as well as higher product yield are attained efficiently using MW assisted MCRs. The present review focuses on the developments in this field covering literature from 2013–2019 and the topic is categorised based on the final products obtained.
Heterocycles are abundant in several pharmaceutical and naturally occurring compounds. Copper-catalyzed multicomponent reactions are a convenient method for easy access to heterocycles. In this review, we focus on the advancement in this field for the past two years.
This Letter reports a Ag-catalyzed
three-component approach for
the N-alkenylation of 2-aminopyridines employing aldehydes and trifluorodiazoethane.
Unlike the known reactions of trifluorodiazoethane with imines, which
generate Mannich adducts, aziridines, or triazolines depending on
the substrates and conditions, this reaction, after Mannich addition,
proceeds via a carbene formation and 1,2-aryl migration sequence to
afford (E)-enaminopyridines. This surprising selectivity,
which is effective for a wide range of aldehydes and 2-aminopyridines,
has been subsequently explored to access trifluoromethylated isoquinolinones.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.