A Microchemical Method for the Determination of Histamine

Johnson, Herbert H.

doi:10.1001/archderm.1955.03730340005002

Cited by 15 publications

(1 citation statement)

References 16 publications

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“…Furthermore, due to their unique physical attributes, aluminosilicates are able to absorb biological active amines such as histamine. 18 It is known that increased plasma levels of serotonin and histamine due to alcohol consumption have been implicated in the pathogenesis of headaches. 19 – 21 …”

Section: Introductionmentioning

confidence: 99%

Potentiated clinoptilolite reduces signs and symptoms associated with veisalgia

Gandy¹,

Laurens²,

Snyman³

2015

CEG

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IntroductionAbundant anecdotal evidence for products claiming to reduce veisalgia after alcohol overindulgence are available on the Internet and as many advertisements in journals. None of these claims are, however, substantiated by research. The aim of this research was to ascertain the validity of such claims for the substance Absorbatox™, a potentiated aluminosilicate (cation exchanger able to bind NH4+, histamine, and other positively charged ions) by investigating the signs and symptoms, as well as blood or breath alcohol levels, in healthy volunteers.MethodsBlood or breath alcohol levels were measured in all volunteers in initial controlled experiments, and symptoms were scored on a diary card for gastrointestinal tract symptoms, as well as other symptoms such as headache and light sensitivity. Eighteen volunteers completed the initial blood alcohol study, which investigated the effect of Absorbatox™ on blood alcohol levels after fasting. The follow-up studies researched the effects of the symptoms and signs of alcohol overindulgence. The “night out” study was completed by ten volunteers in a typical controlled environment, which was followed by the real-life four-leg crossover study. In the crossover study, volunteers (number =25 completers) had to fill matching diary cards to containers of two placebo and two active drugs after a night out where they themselves decided on the container (color coded) to be used and the amount of alcohol to be consumed.ResultsAbsorbatox™ had no effect on blood alcohol levels, but it significantly reduced the symptoms and signs of veisalgia by approximately 40%–50%.ConclusionThis research indicates that Absorbatox™ does not have an effect on blood- or breath-alcohol levels. Furthermore, treatment with Absorbatox™ resulted in an overall significant reduction in central nervous system and gastrointestinal tract symptoms associated with veisalgia, warranting further investigation.

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Section: Introductionmentioning

confidence: 99%