A micro liquid chromatographic assay for the determination of plasma-unbound atenolol

Cheng, Fu‐Chou; Chen, Ying‐Tsung; Kuo, Jon‐Son; Chen, Sy-Huah; Chang, Li-Chun

doi:10.1016/s0731-7085(96)01760-8

Cited by 5 publications

(1 citation statement)

References 25 publications

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“…1). The ultrafiltration technique has been applied to plasma processing for drug and bio genic amine monitoring assay [20]. The ultrafiltration procedure offers the advantages of simplicity and high reproducibility, eliminating problems associated with the precipitation procedures (e.g., sample dilution, in complete protein precipitation, drug coprecipitation, acid catalyzed degradation etc.…”

Section: Methodsmentioning

confidence: 99%

Pharmacokinetic study of metoprolol in rabbit plasma by capillary electrophoresis with laser-induced Fluorescence detection

Chen

Yang

2012

J Anal Chem

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This work described a sensitive method for determination of metoprolol in rabbit plasma. The method involved purification by ultrafiltration, derivatization with Fluorescein isothiocyanate, separation by capillary electrophoresis and determination by laser induced fluorescence detector. Other components in plasma including a variety of amino acids and proteins did not interfere with the determination of metoprolol under experimental conditions. The assay had a wide range (2.0-500 ng/mL) of linearity and a detection limit of 0.8 ng/mL. The intra and inter day precisions of the QC samples were satisfactory with RSD less than 10% and accuracy within 10%. This method was successfully applied to pharmacokinetic study of meto prolol in rabbit blood.

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Section: Methodsmentioning

confidence: 99%

Pharmacokinetic study of metoprolol in rabbit plasma by capillary electrophoresis with laser-induced Fluorescence detection

Chen

Yang

2012

J Anal Chem

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Chemiluminescence determination of atenolol in biological fluids by a europium-sensitized permanganate-sulfite system

2008

Microchim Acta

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Determination of metoprolol in rabbit blood using capillary electrophoresis with laser-induced fluorescence detection

Chen

Yang

Zhang

2011

Chinese Chemical Letters

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A micro liquid chromatographic assay for the determination of plasma-unbound atenolol

Cited by 5 publications

References 25 publications

Pharmacokinetic study of metoprolol in rabbit plasma by capillary electrophoresis with laser-induced Fluorescence detection

Pharmacokinetic study of metoprolol in rabbit plasma by capillary electrophoresis with laser-induced Fluorescence detection

Chemiluminescence determination of atenolol in biological fluids by a europium-sensitized permanganate-sulfite system

Determination of metoprolol in rabbit blood using capillary electrophoresis with laser-induced fluorescence detection

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