A method using a liquid chromatographic-electrospray-mass spectrometric assay for the determination of antimigraine compounds: preliminary pharmacokinetics of MDL 74,721, sumatriptan and naratriptan, in rabbit

High-performance liquid chromatographic determination of sumatriptan after in vitro transdermal diffusion studies

“…They include HPLC with UV/Visible detection [1][2][3][4][5][6][7], MS [8][9][10][11][12][13], electrochemical detection [14,15] and capillary electrophoresis [16,17]. Several of the methods and infrastructure are not available to small laboratories.…”

Determination of antimigraine compounds rizatriptan, zolmitriptan, naratriptan and sumatriptan in human serum by liquid chromatography/electrospray tandem mass spectrometry

“…Sumatriptan has been quantitated by HPLC,19–24 capillary electrophoresis25 and LC/MS26–29 from various biological matrices. An LC/MS/MS assay has been reported for the determination of naratriptan from rabbit plasma 27. At this time, no method is available in the literature for the determination of rizatriptan and zolmitriptan from human serum.…”

Challenges in the simultaneous quantitation of sumatriptan and naproxen in human plasma: Application to a bioequivalence study

“…Several methods have used either liquid-liquid extraction (LLE) [9,11,21] or solid phase extraction (SPE) [13,[16][17][18][19]22] for the extraction of SUM (as a single analyte) from human plasma. However, protein precipitation (PP) has been successfully established for sample clean-up of NAP from human plasma [32,47,48].…”

“…Several methods are reported for the determination of SUM in biological matrices by HPLC with fluorescence [9,10], electrochemical [11][12][13], ultraviolet detection [14,15] and LC-MS/MS [16][17][18][19][20][21][22]. In majority of these published methods, the sensitivity was ≥1 ng/mL [9][10][11][12]16,20,22] with high volume of biological fluid (≥0.5 mL) for sample processing [9][10][11][12][13]16,17,[19][20][21].…”