A method for the bioassay of antisecretory activity in the conscious rat with acute gastric fistula: Studies with cimetidine, somatostatin, and the prostaglandin E2 analog Ro 21-6937

Gallo-Torres, Hugo E.; Kuhn, Douglas C.; Witt, Constance G.

doi:10.1016/0160-5402(79)90027-5

Cited by 14 publications

(1 citation statement)

References 29 publications

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“…Trimoprostil, a prostaglandin E2 derivative, has been reported to be an orally active inhibitor of gastric hypersecretion in experi mental animals (3)(4)(5) and man (6). Further more, this prostanoid protects the gastric mucosa of rats from lesions induced by various necrotizing agents, and it exhibits an antiulcer effect on various acute gastric and duodenal ulcers in rats (5).…”

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Effects of Trimoprostil on Healing and Recurrence of Acetic Acid-induced Gastric Ulcer in Rats

Umeda

Nakamura

1986

Japanese Journal of Pharmacology

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Abstract-Chronic gastric ulcers were produced by injection of 20% acetic acid (0.05 ml) into the submucosal layer of the rat stomach in order to determine the effects of the prostanoid trimoprostil on the healing and recurrence of ulcers. Local injection of acetic acid solution produced large demarcated ulcers in all animals on day 5, which rapidly decreased to reach low levels on days 40-80 and then became exacerbated on day 100. The exacerbation of the ulcer is probably recurrence. Trimoprostil was administered ad libitum in drinking water containing 0.1, 0.3 and 1.0 /.cg/ml (average dose 12.4, 37 and 124 /cg/kg/day) for a period of 14 days (day 1-15) to assess its effect on healing and for a period of 40 days (day 60-100) to assess its ability to prevent recurrence. The higher two doses of trimoprostil accelerated the spontaneous healing of the ulcers. Furthermore, trimoprostil, at both doses, prevented the observed recurrence of this type of ulcer. Trimoprostil dose-dependently (30-300 iig/kg, p.o.) inhibited gastric secretion in pylorus ligated rats. Cimetidine at the antisecretory dose (1 mg/ml, 132 mg/kg/day) failed to affect the healing process of gastric ulcers, but tended to prevent the recurrence of gastric ulcers. Our present study suggests that trimoprostil is a promising antiulcer drug for the treatment of chronic gastric ulcer.

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